DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	557	Identity:	163/557 - (29%)
Similarity:	267/557 - (47%)	Gaps:	70/557 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFLLSTMTQSSGG--ANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQ-----MKPKLA 67
            |:...||.:|..|.|  .||| |:.|.. ||.|....|:..|.|||||:||:..     ||.|.:
Zfish     3 LVVCFLSLLTVFSAGQCGNIL-VWHTEG-SHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKES 65

  Fly    68 ---THENITVIIAPPTEERQRYIKE--YMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPN 127
               :::|.:|  :...::.|.::.|  :.:....|:.:..:..:|..     .|..:::.|....
Zfish    66 DRFSYQNFSV--STSAQDMQDFLDELLHFSVFEMEQLNLLQIQMKFF-----DLGSRHQDMGLSY 123

  Fly   128 VKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWV-GIPLPF---------M 175
            ...|.::|::       |||::....|           ..|..|::.| .:||.|         |
Zfish   124 CDGILKSPELMDKLKTGKFDVLLSDPM-----------YPCSDIVAEVLNVPLVFTLRFSIAHTM 177

  Fly   176 DTIVGNV-NDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANE 239
            :.|.|.: ..|||||.   |::.....|.|..|..|...|..|..|..:...|.:.:|...|...
Zfish   178 ERICGQIPAPPSYVPG---AMSKLTDKMSFTERIFNTLFYLSMDTFSIIAWKKFDNYYTEYFGRP 239

  Fly   240 LEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKA-DEG 303
               .:|.||..|..:.....:...|.| ||.||....|||:.. ..|.||||::.:|:..: |:|
Zfish   240 ---TSYCEMMGRADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDG 299

  Fly   304 AIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKP---GNASNIFFGNWLPQDDI 365
            .:.|:||:.:  :....:..:.:...|:::||:|:|::..  .||   |..:.|:  .|:||:|:
Zfish   300 IVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGG--EKPDTLGENTRIY--KWMPQNDL 358

  Fly   366 LAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLD-ILTMTEHELE 429
            |.||.|:.||||.|..|:.||.|||||||.:|:||||..|...||..|....:| |.:|...||.
Zfish   359 LGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELV 423

  Fly   430 QTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNL 494
            ..:..|:.:|:|:|...:.|.::.|||:......::|.|:|:|::||.||:....:..:...:.|
Zfish   424 DKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCL 488

  Fly   495 DVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKA 531
            ||:..:..| |.|::.|.|...|...:...:.|:||:
Zfish   489 DVFAFLTTV-LTLVLYICFKMAKFFIMRCCFRSKRKS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	147/499 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	132/453 (29%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	155/537 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740