DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	159/531 - (29%)
Similarity:	254/531 - (47%)	Gaps:	66/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVV---SSV--PPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKE 104
            ||::....|::.|.:|||.|||:   :||  .||.| ..:..:..|.|.....:.|     ....
  Rat    34 SHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKET-SDLKFVTFPTSFSSHDLEN-----FFTR 92

  Fly   105 KPSIW------NTMKSIFSSLALLIDKQVD----VLEDPRFQELYLNK--GNKFDVVFVGFFFNT 157
            ..::|      :|..|.|..|...||:..|    |.::....:.::.|  .:||||||
  Rat    93 FVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVF------- 150

  Fly   158 YQVALG-------ARFNCPVIISWSGPPMMMVNEVLGN---PELSSVPQMHISAPPGQPMNFQQR 212
             ..|:|       .....|.:.|....|...:.:.:|.   |. |.|| |..|...|| |.|.:|
  Rat   151 -SDAIGPCGELIAELLQIPFLYSLRFSPGYTIEKYIGGVLFPP-SYVP-MIFSGLAGQ-MTFIER 211

  Fly   213 MQNFASTLGFNA-LNIFLNHKYNKFYDRLWSKDKSMP-TFAQAKRNVSLAFCNGHGISEGPIRPN 275
            :.|....|.|:. ...|...|::.||    ||....| |.|:......:.....:...|.| .|.
  Rat   212 VHNMICMLYFDFWFQTFREKKWDPFY----SKTLGRPTTLAEIMGKAEMWLIRSYWDLEFP-HPI 271

  Fly   276 VPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLK 339
            .|.|..|||:..| ...|||:||::|:: .|:||.::|||||.::  ::..|....|...|:.:.
  Rat   272 SPNVDYIGGLHCK-PAKPLPKDIEDFVQSSGEHGVVVFSLGSMVR--NMTEEKANIIAWALAQIP 333

  Fly   340 QQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVF 404
            |:|:|:: |.|..|....|....|||||:|:|.|||.|.|:||.|..|:.||.:||:||:.:|:|
  Rat   334 QKVLWRF-DGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLF 397

  Fly   405 ADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVV 469
            .:|..|...:||.|..:::...|:...:...|::|||.||.|.|.....|.::.|:|..|.:..|
  Rat   398 GEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAV 462

  Fly   470 YWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI--YIIAALVLYIVFIINKIVWKFVWRKLFGKSN 532
            :|.|:|:||.||.|::|...::.:...::||:  :::..:.:.:|..:.  .:.||:|..
  Rat   463 FWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTVVLALK--CFLFVYRFF----- 520

  Fly   533 KVSKGKKVKKQ 543
             |.|.||.|.:
  Rat   521 -VKKEKKTKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	150/498 (30%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	154/516 (30%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	157/526 (30%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	83/222 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840