DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	533	Identity:	151/533 - (28%)
Similarity:	245/533 - (45%)	Gaps:	74/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVV---SSVPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVK--- 103
            ||::....::..|..:||::|||   ||...:........|.|.....|:..:...:..::|
Zfish    32 SHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPLYTSITVDNGVFDDDFMEKFLPHLLKIQR 96

  Fly   104 EKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQ-----------ELYLN--KGNKFDVVFVGFFF 155
            :..|.||.|        .|.|:.:..:.:...|           |..:|  |...:|||.....:
Zfish    97 QGKSFWNEM--------ALADEMIHFVTETHKQSCNMTAILFENETLMNSLKDAAYDVVLTDPAY 153

  Fly   156 NTYQVALGARFNCPVI--ISWSGPPMMMVNEVLGNPELSSVPQMHISAPPG-----QPMNFQQRM 213
            .: .|.|..|...|::  :.|:         |.|.......|......|..     ..|.|.||:
Zfish   154 GS-GVLLAHRLGLPLVYNVRWT---------VYGEAHFDIAPSPLSYVPVSGLQLTDKMTFSQRV 208

  Fly   214 QNFASTLGFNALNIFLNHKYNKF----YDRLWSKDKSMP--TFAQAKRNVSLAFCNGHGISEGPI 272
            .|..:       .|.:.:||:|.    |..|..|... |  .|....::..|.........|.|
Zfish   209 MNMMT-------YIMIRYKYSKNFGSPYQELTQKYFG-PNVNFFSLLQDADLWLMRNDFTFEFP- 264

  Fly   273 RPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLS 336
            ||.:|.|:.:||.|.| ...|||.|::||:: .|:||.|:.|||: :.|: :..|:...|....:
Zfish   265 RPTMPNVVYMGGFQCK-PAKPLPGDLEEFVQSSGEHGVIMMSLGT-VFGQ-LLSELNDEIAAAFA 326

  Fly   337 SLKQQVIWKWEDPKNTPGK-SANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLA 400
            .|.|:|||::..|:  |.. ..|.|...||||:|:|.|||.|||:.|.|..|:.||.|||||::.
Zfish   327 QLPQKVIWRYTGPR--PANLGNNTLIVNWLPQNDLLGHPKTKLFVAHGGTNGLQEAIYHGVPIVG 389

  Fly   401 LPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQ 465
            ||:..|||.|..::.|.|....:..||||...|..|:|||:.||.|.:.::..|:|:.|:|:.|.
Zfish   390 LPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFLEALKEVLHNPSYRENMQRLSKLHHDQPMKPL 454

  Fly   466 ESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKLFGK 530
            :..::|.|:|:|:.||.|:::....|::|...::|:.:...|::.:..::.....|:....||
Zfish   455 DRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDVILTLMLMVLVFVLLTVYTMKYFCLCLF-- 517

  Fly   531 SNKVSKGKKVKKQ 543
                  .||||::
Zfish   518 ------RKKVKRE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	144/500 (29%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	147/518 (28%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	151/531 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840