Protein Alignment Ugt37D1 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 157/532 - (29%)
• Similarity: 262/532 - (49%)
• Gaps: 75/532 - (14%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVS-----SVPPKVTHKSINHIVVPMS---AEDEKVLNDGMAGM 101
            ||::...:|:..|.::||.|||::     |..|. :..::...|.|:|   .|.|.::..    :
Human    34 SHWMNIKTILDELVQRGHEVTVLASSASISFDPN-SPSTLKFEVYPVSLTKTEFEDIIKQ----L 93

  Fly   102 VKE-----KPSIWNTMKSIFSSLALLIDKQVDVLEDPRF-QELYLNK-------GNKFDVVFVGF 153
            ||.     |.:.|    |.||.:..::....|:|.  :| :::..||       .::||||....
Human    94 VKRWAELPKDTFW----SYFSQVQEIMWTFNDILR--KFCKDIVSNKKLMKKLQESRFDVVLADA 152

  Fly   154 FFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGN----PELSSVPQMHISAPPGQPMNFQQRMQ 214
            .| .:...|......|.:.|....|...:.:..|.    |....|....:|    ..|.|.:|::
Human   153 VF-PFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELS----DQMTFIERVK 212

  Fly   215 NFASTLGFNA-LNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLA-----FCNGHGISEGPIR 273
            |....|.|.. ..||...|:::||..:..:..:: :...||.::.|.     |...|     |:.
Human   213 NMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTL-SETMAKADIWLIRNYWDFQFPH-----PLL 271

  Fly   274 PNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSS 337
            |||..|   ||:..| ...|||::::||:: .|::|.::|||||.:  .:...|....|...|:.
Human   272 PNVEFV---GGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNTSEERANVIASALAK 330

  Fly   338 LKQQVIWKWEDPK-NTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLAL 401
            :.|:|:|:::..| :|.|.:.. || ||:||:|:|.|||.:.||||.|..|:.||.|||:||:.:
Human   331 IPQKVLWRFDGNKPDTLGLNTR-LY-KWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGV 393

  Fly   402 PVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQE 466
            |:|||||.|...:.|.|..:.|...|:...:...|:|.||.:|.|.:.....|:::.|:|:.|.:
Human   394 PLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLD 458

  Fly   467 SVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIY-IIAALVLYIVFIINK---IVWKFVWRKL 527
            ..|:|.|:|:||.||.|::.....:.:...::||:. .:.|.|..::|||.|   .|||||
Human   459 RAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFV---- 519

  Fly   528 FGKSNKVSKGKK 539
              ::.|  |||:
Human   520 --RTGK--KGKR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	144/500 (29%)
		UDPGT	45..530	CDD:278624	153/521 (29%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	148/507 (29%)
		UDPGT	24..524	CDD:278624	154/527 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840