DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	571	Identity:	162/571 - (28%)
Similarity:	273/571 - (47%)	Gaps:	97/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVV---SSVPPKVTHKSI 79
            :.|.:|..:..||.|..:| ||.... ||::....:::.|..||||||||   :|...|......
Zfish     7 LCLFSLLCVLSGTYGGKVL-VFPLDG-SHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFY 69

  Fly    80 NHIVVPMSAE-DEK------------------VLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDK 125
            :.|.:|.:.. ||:                  |||     .|:.:..|....|::...:..::|:
Zfish    70 SSITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLN-----RVRLEFEIMMKFKTMHEDMLQMMDR 129

  Fly   126 QVDVLEDPRFQELYLN--KGNKFDVVFVGFFFNTYQVALGA------RFNCPVI--ISWSGPPMM 180
               :|||    |..:|  :..|||||..       ..|:|.      :||.|::  :.|:
Zfish   130 ---MLED----EKVMNSIQDAKFDVVLA-------DPAVGGGPILAYKFNIPLVFNVRWT----- 175

  Fly   181 MVNEVLGNPELSSVPQMHISAP-PG----QPMNFQQRMQN-FASTLGFNALNIFLNHKYNKFYDR 239
                :.|....:..|......| ||    ..|:|.||::| ....:....:.|.:...|..|..:
Zfish   176 ----IQGEGHFAIAPSPLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHK 236

  Fly   240 LWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE- 303
            .:..:   .|:....::..:.........|.| ||.:|.::.:.|.|.| ...|||.|:::|:|
Zfish   237 HFGPN---VTYFSLFQDADIWLMRNDFTFEFP-RPTMPNIVYMSGFQCK-PAKPLPNDLEKFVES 296

  Fly   304 KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKN-TPGKSANILYKKWLPQ 367
            .|:||.|:.|||:.:  ..:..::...|....:.|.|:|||::..|:. |.|.  |.|..:||||
Zfish   297 SGEHGVIVMSLGTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGN--NTLLVEWLPQ 357

  Fly   368 DDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDE 432
            :|:|.||::|:|:.|.|..|:.||.|||||:|.||:..|||.|..::.|.|....:.:||||...
Zfish   358 NDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTV 422

  Fly   433 FKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASN 497
            |..|:|||:.||.|.:.::..|:|:.|:||.|.:..::|.|:|:|:.||.|:::....|::|..:
Zfish   423 FLEALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYH 487

  Fly   498 NLDIYIIAALVLYIVFIINKIVWKFVWRKLFGKSNK-----VSKGKKVKKQ 543
            ::|:            |:..:|..||:..:.|.:.|     |.: ||||::
Zfish   488 SIDV------------ILTLMVTGFVFALMIGYTIKYFCLCVFR-KKVKRE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	149/526 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	147/524 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	157/554 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840