DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	153/559 - (27%)
Similarity:	276/559 - (49%)	Gaps:	78/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTE---GANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77
            ||:..|||      ||   ..|:  |......||::....:::.|.::.|:|||:::......:.
  Rat     8 LLIFPLAL------TEIVLSGNV--VIWPSDGSHWLNIKILLEELVQRNHSVTVLAASETLFINS 64

  Fly    78 S----INHIVVPMSAEDEKVLNDGMAGMVKEKPSIW-------NTMKSIFSSLALL------IDK 125
            |    |:...:|:|....|:     ..|::...::|       .||.:.:..|..|      |:|
  Rat    65 SPDAFISFEEIPVSYTRSKI-----DEMIEHMIALWLDHRPTPLTMWAFYKELGKLFAAFYKINK 124

  Fly   126 QV--DVLEDPRFQELYLNKGNKFDVVF---VGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEV 185
            |:  .||::.... ..|.||. |||:.   |........:.||    .|.:.:....|...|...
  Rat   125 QICDGVLKNATLM-ARLQKGG-FDVLISDPVTMCGELVALKLG----IPFVYTLRFSPAFTVERH 183

  Fly   186 LGN--PELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALN-IFLNH--KYNKFYDRLWSKDK 245
            .|.  ..:|.||.. :|....| |.|.:|::|   |:.::..: ||.::  ::|.:|.|:..:.
  Rat   184 CGKIPTPVSYVPAA-LSELTDQ-MTFGERVKN---TISYSLQDYIFKSYWGEWNSYYSRVLGRP- 242

  Fly   246 SMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGA 309
              .|..:......:.....:...|.| ||.:|....:||:..| ...|||::::||:: .|:||.
  Rat   243 --TTLCETMGKAEIWLMRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFVQTSGEHGV 303

  Fly   310 ILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGK-----SANILYKKWLPQDD 369
            ::|||||.:|  ::..|....|...|:.:.|:|:|:::      ||     .:|.....|:||:|
  Rat   304 VVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYK------GKIPATLGSNTRLFDWIPQND 360

  Fly   370 ILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFK 434
            :|.|||.:.||||.|..|:.||.|||:||:.:|:|||||.|...:.|.|..:::.:.|:...:..
  Rat   361 LLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSADLL 425

  Fly   435 AAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNL 499
            :|::.||..|.|.:.....|:::.|:|:.|.:..|:|.|:|:||.||.|::.....:::...::|
  Rat   426 SAVRAVINEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSL 490

  Fly   500 DI--YIIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSK 536
            |:  :::|.:...|:.:|...:  ||::|: ||:.|.:|
  Rat   491 DVIGFLLACMASAILLVIKCCL--FVFQKI-GKTGKKNK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	139/524 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	140/519 (27%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	144/535 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910