DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt305A1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	125/564 - (22%)
Similarity:	221/564 - (39%)	Gaps:	101/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSINHIVVPMSAEDEKVLN 95
            |.||||.:.::...::......:...|...||::.|:|:.|.....|.::.:|......:..|:.
  Fly    20 EAANILCLVSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHLPNEYDVMK 84

  Fly    96 DGMAGMVKEKPSIWNTMKSIFSSL-----------ALLIDKQVDVLEDPRFQELYLNKGNKFDVV 149
               ...:.|:|..:.:|.::...|           |||   ..|.:...| .||......::|::
  Fly    85 ---RHFLLEEPREYISMVTLNQLLVWYEVLLGSCRALL---NSDTMSSKR-PELTAQLSMEYDLI 142

  Fly   150 FVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSS------------VPQMHISAP 202
            ..       .|..|.......:..|...|::.::.....|:|.|            :|. :||..
  Fly   143 IT-------DVTQGIECLMDSVSGWRSKPVLGLSAGKLTPDLMSLLRAENTINAARIPH-YISQV 199

  Fly   203 PGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGI 267
            | :.|.|..|:.|.........:::.:.   ......|...:.:.|       .:.|...|.|
  Fly   200 P-KTMGFWNRLHNHIMYYAEPLIHLVIT---RPVLSELMKTENAFP-------KLQLVLLNTH-- 251

  Fly   268 SEGPIRPNV----PGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVV 328
               |....|    |||||:||:.:|::..|||..||||.||...|.:..::          |.:.
  Fly   252 ---PTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIVYINM----------PYIE 303

  Fly   329 KTIFKGLSSLKQQV--------IWKWEDPKNTPGKSANI--LYKKWLPQDDILAHPKLKLFITHA 383
            ....:||.::...:        ||..|..:..|.|..|:  |:.....|.||||...:|.|:.|.
  Fly   304 YMNDQGLKAMYTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSLQQDILAMQYVKGFLNHG 368

  Fly   384 GKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAK 448
            ....:.||.::|||::.||:..::..||.:::....|:.|.:...:......|:..:::..::..
  Fly   369 DSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFIS 433

  Fly   449 TLKSFSQLYRDRPLSPQESVVYWTEYVIRH-----HGAAHMQSPLVHMNFIASNNLDIYIIAALV 508
            .|......:|.||.|..|..|:..|.:|..     |.|   |:..:..||..:|:||:..:..:|
  Fly   434 ALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHFA---QTETLAQNFFVANSLDVLTVPLIV 495

  Fly   509 LY--IVFIINKIVWKFVWRKLFGKSNK--------VSKGKKVKK 542
            |.  :|.:.|     .|:....|.|.:        :.|.||.||
  Fly   496 LLAAVVSLAN-----LVYVLYTGGSKRQQTLEKAVLKKRKKSKK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	115/524 (22%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	113/528 (21%)
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	61/233 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445810
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950