Protein Alignment Ugt37D1 and UGT2A2

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 150/544 - (27%)
• Similarity: 267/544 - (49%)
• Gaps: 92/544 - (16%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKS----INHIVVPMSAEDEKV--LNDGMAGM-V 102
            ||::....|::.|.::.|||||::|......:.:    :|..|:|:|.:...:  |.:.|..: :
Human    40 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 104

  Fly   103 KEKP---SIWNTMKSIFSSLALLIDK--QVD------VLEDPRFQELYLNKGNKFDVVFVGFFFN 156
            ..:|   :||    :.:..|..|:|.  |::      ||::|:.. ..|.||. |||:...
Human   105 DHRPTPLTIW----AFYKELGKLLDTFFQINIQLCDGVLKNPKLM-ARLQKGG-FDVLVAD---- 159

  Fly   157 TYQVALGARFNCPVIISWSGPPMMMVNEVLGNPEL-------SSVPQMH---ISAPPG------- 204
                        ||.|...     :|...||.|.:       :|..:.|   |.||..
Human   160 ------------PVTICGD-----LVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALS 207

  Fly   205 ---QPMNFQQRMQNFASTLGFNALN-IFLNH--KYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCN 263
               ..|.|.:|::|   |:.::..: ||.::  ::|.:|.::..:.   .|..:......:....
Human   208 ELTDQMTFGERIKN---TISYSLQDYIFQSYWGEWNSYYSKILGRP---TTLCETMGKAEIWLIR 266

  Fly   264 GHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEV 327
            .:...|.| ||.:|....:||:..| ...|||::::||:: .||:|.::|||||.:|  ::..|.
Human   267 TYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NLTEEK 327

  Fly   328 VKTIFKGLSSLKQQVIWKWEDPK-NTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEA 391
            ...|...|:.:.|:|:|:::..| .|.|.:..:.  .|:||:|:|.|||.|.||||.|..|:.||
Human   328 ANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGIYEA 390

  Fly   392 QYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQL 456
            .||||||:.:|:|||||.|...:.|.|..:::.|.|:...:..:|::.||..|.|.:.....|::
Human   391 IYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRI 455

  Fly   457 YRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI--YIIAALVLYIVFIINKIV 519
            :.|:|:.|.:..|:|.|:|:||.||.|::.....:.:...::||:  :::..:...|..:|...:
Human   456 HHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCL 520

  Fly   520 WKFVWRKLFGKSNKVSKGKKVKKQ 543
              |..:| |||.     |||.|::
Human   521 --FSCQK-FGKI-----GKKKKRE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	139/511 (27%)
		UDPGT	45..530	CDD:278624	144/529 (27%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	142/524 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840