DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	563	Identity:	157/563 - (27%)
Similarity:	253/563 - (44%)	Gaps:	97/563 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TEGANIL---GVFTSHSPSHFIVHMSIMKTLAEKGHNVTV-VSSVPPKVT---HKSINHIV--VP 85
            |...|:|   |.:     ||:....:::..|..:.|.||| |.|..|.:.   .:...::|  ||
Zfish    20 THAGNVLVLPGEY-----SHWQNMRNVVDELLNRNHTVTVLVCSASPTINFTQQERFQYLVFEVP 79

  Fly    86 MSAEDEKVLNDGMAGMVKEKPSIW------NTMKSIFSSLALLIDKQVDVLEDPRFQELYLN--- 141
            :||::       :.|..:|...||      |.:::....:.||  .:|.|:.......:..|
Zfish    80 LSAQE-------LDGASEELIHIWTQHPSPNRLQTALQIIELL--GRVRVMHRAMCDSMLRNDAL 135

  Fly   142 ----KGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISAP 202
                ...||||:|....|....: |......|:::|....|...:..:.|          .:.||
Zfish   136 IAQLSALKFDVLFNDPMFMCADL-LAEMLGLPLVLSVRISPGFCLERMCG----------QMPAP 189

  Fly   203 PG----------QPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNV 257
            |.          ..|.|.:|:||..:.:.|:.          .||...|....|..|....|
Zfish   190 PSFVPITQTVLTDRMCFMERVQNMIANIVFSV----------SFYIVAWISLDSYYTDVLGK--- 241

  Fly   258 SLAFCNGHGIS-----------EGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAI 310
            ....|...|.:           |.| ||..|....:||:..| ...||.::::||:: .|.||.:
Zfish   242 PTTMCETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKEMEEFVQSSGDHGVV 304

  Fly   311 LFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSA-NILYKKWLPQDDILAHP 374
            :|||||.:|  ::..|...||...|..:.|:|:|::..  .||...| |.....|:||:|:|.||
Zfish   305 VFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSG--KTPETLAPNTKIYDWIPQNDLLGHP 365

  Fly   375 KLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKE 439
            |.|.||||.|..|:.||.||||||:.||:|||||.|...:...|..:.|.:.||:..:...|:|.
Zfish   366 KTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKT 430

  Fly   440 VIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYII 504
            |:.||.|.:::...|:::.|:|:.|.:..|||.|:|:|:.||.|::.....:::...:.||   :
Zfish   431 VLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLD---V 492

  Fly   505 AALVLYIVFIINKIVWK----FVWRKLFGKSNKVSKGKKVKKQ 543
            ||.:|.|..:|. .:|.    |::|:...|:....|.:|.|.:
Zfish   493 AAFLLSIAALIT-FLWVKACCFLFRRCVRKTRPERKTQKSKNE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	148/526 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	149/530 (28%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	152/545 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	86/236 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910