Protein Alignment Ugt37D1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 157/572 - (27%)
• Similarity: 265/572 - (46%)
• Gaps: 77/572 - (13%)

  Fly     6 STWIGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSP---SHFIVHMSIMKTLAEKGHNVTVV 67
            :|.:...|..|...||.|.::....|...:|.|     |   ||::....:::.|..:||...|:
Human     2 ATGLQVPLPWLATGLLLLLSVQPWAESGKVLVV-----PIDGSHWLSMREVLRELHARGHQAVVL 61

  Fly    68 SSVPPKVT-H-KSINHIVVPMSA----EDE---KVLNDGMAGMVKEKPSIWNTMKSIFSSLALLI 123
            :   |:|. | |..|...:...|    :||   .||.........|     :.:|..|.|:|:|.
Human    62 T---PEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETE-----HFLKKFFRSMAMLN 118

  Fly   124 DKQ-------VDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIIS--WSGPPM 179
            :..       |::|.:..... :|| ...||||.      |..|.|     |..:::  .|.|.:
Human   119 NMSLVYHRSCVELLHNEALIR-HLN-ATSFDVVL------TDPVNL-----CAAVLAKYLSIPTV 170

  Fly   180 MMVNEV----------LGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYN 234
            ..:..:          ..||. |.:|:  :.......|.|.||::|....|..:.:....:..|.
Human   171 FFLRNIPCDLDFKGTQCPNPS-SYIPR--LLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYA 232

  Fly   235 KFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQ 299
            .....|:.::.|:   .....:.|:....|..:.:.| ||.:|.::.||||...:: .||.::.:
Human   233 SLASELFQREVSV---VDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFE 292

  Fly   300 EFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILY 361
            .::. .|:||.::|||||.:  ..|..:....|...|..:.|.|:|::..  |.|.   :.|.:.
Human   293 AYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTIL 352

  Fly   362 KKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLA 426
            .|||||:|:|.||..:.||||||..||.|:..:||||:.:|:|.||..||.::...|.|:.|.:.
Human   353 VKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL 417

  Fly   427 TLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH- 490
            .:..::.:.|:|.||.:..|.:.:...|.|::|||:.|.:..|:|.|:|:||.||.|:: |..|
Human   418 EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHD 481

  Fly   491 MNFIASNNLDIY-IIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVK 541
            :.:...::||:. .:.|:||.:.||..|.. .:.:||..||..:|.|..|.|
Human   482 LTWYQYHSLDVIGFLLAVVLTVAFITFKCC-AYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	140/522 (27%)
		UDPGT	45..530	CDD:278624	141/517 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	146/536 (27%)
		egt	<262..508	CDD:223071	87/253 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840