Protein Alignment Ugt37D1 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 147/546 - (26%)
• Similarity: 260/546 - (47%)
• Gaps: 45/546 - (8%)

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK--- 77
            |...||.|.::....|...:|.|.|..||  ::.....::.|..:||...|::   |:|...
Human    12 LATGLLLLLSVQPWAESGKVLVVPTDGSP--WLSMREALRELHARGHQAVVLT---PEVNMHIKE 71

  Fly    78 ----SINHIVVPMSAED-EKVLNDGMAGMVKEKPSI--WNTMKSIFSSLALLIDK-QVDVLEDPR 134
                ::....||.:.:: ::|......|..:.:..:  ::...:|.::::|.:.: .|::|.:..
Human    72 EKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEA 136

  Fly   135 FQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLG----NPELSSVP 195
            ... :|| ...||||... ..|.....|....:.|.:..|...|..:  :..|    ||. |.:|
Human   137 LIR-HLN-ATSFDVVLTD-PVNLCGAVLAKYLSIPAVFFWRYIPCDL--DFKGTQCPNPS-SYIP 195

  Fly   196 QMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLA 260
            :  :.......|.|.||::|....|..:.:....:..|......|:.::.|:.....   ..|:.
Human   196 K--LLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVS---YASVW 255

  Fly   261 FCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQ 324
            ...|..:.:.| ||.:|.::.||||.. :...||.::.:.::. .|:||.::|||||.:  ..|.
Human   256 LFRGDFVMDYP-RPIMPNMVFIGGINC-ANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIP 316

  Fly   325 PEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGG 387
            .:....|...|..:.|.|:|::..  |.|.   :.|.:..|||||:|:|.||..:.||||||..|
Human   317 EKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAGSHG 378

  Fly   388 VAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKS 452
            |.|:..:||||:.:|:|.||..||.::...|.|:.|.:..:..::.:.|:|.||.:..|.:.:..
Human   379 VYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR 443

  Fly   453 FSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFII 515
            .|.|::|||:.|.:..|:|.|:|:||.||.|:: |..| :.:...::||:. .:.|:||.:.||.
Human   444 LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT 507

  Fly   516 NKIVWKFVWRKLFGKSNKVSKGKKVK 541
            .|.. .:.:||..||..:|.|..|.|
Human   508 FKCC-AYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	132/506 (26%)
		UDPGT	45..530	CDD:278624	131/504 (26%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	138/520 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840