Protein Alignment Ugt37D1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_652627.2
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 154/533 - (28%)
• Similarity: 258/533 - (48%)
• Gaps: 76/533 - (14%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT---HKSINHIVVPMSAEDEKVLNDGMAGMVKEKP 106
            ||:....|:::.|..:||.|.||.   |:|:   .:|:|..|...|.  ...|.|    :.:|..
Human    36 SHWFTMRSVVEKLILRGHEVVVVM---PEVSWQLGRSLNCTVKTYST--SYTLED----LDREFK 91

  Fly   107 SI----WNT-MKSIFSSLALLIDKQVDVLE-----------DPRFQELYLNKGNKFDVVFVGFFF 155
            :.    |.. ::||:|   ||:....|:.:           |.:..| || |.:.||.||:..|
Human    92 AFAHAQWKAQVRSIYS---LLMGSYNDIFDLFFSNCRSLFKDKKLVE-YL-KESSFDAVFLDPF- 150

  Fly   156 NTYQVALGARFNCPVIIS--WSGPPMMMVNEVLGN---------PELSSVPQMHISAPPGQPMNF 209
                      .||.:|::  :|.|.::....:|.:         ..||.||::.:..  ...|.|
Human   151 ----------DNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGF--SDAMTF 203

  Fly   210 QQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMP-TFAQAKRNVSLAFCNGHGISEGPIR 273
            ::|::|....|..:    .|.|::.|....:.|:....| |......:.|:.......:.:.| :
Human   204 KERVRNHIMHLEEH----LLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYP-K 263

  Fly   274 PNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSS 337
            |.:|.:|.||||.. .:..|||.:.:.::. .|:||.::|||||.:  ..|..:....|...|..
Human   264 PVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGK 325

  Fly   338 LKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLA 400
            :.|.|:|::..  |.|.   :.|.:..|||||:|:|.||..:.||||||..||.|:..:||||:.
Human   326 IPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVM 387

  Fly   401 LPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQ 465
            :|:|.||..||.::...|.|:.|.:..:..::.:.|:|.||.:..|.:.:...|.|::|||:.|.
Human   388 MPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPL 452

  Fly   466 ESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFIINKIVWKFVWRKLF 528
            :..|:|.|:|:||.||.|:: |..| :.:...::||:. .:.|:||.:.||..|.. .:.:||..
Human   453 DLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCC-AYGYRKCL 515

  Fly   529 GKSNKVSKGKKVK 541
            ||..:|.|..|.|
Human   516 GKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_652627.2	GT1_Gtf-like	33..471	CDD:340817	128/459 (28%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	150/524 (29%)