Protein Alignment Ugt37D1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 156/566 - (27%)
• Similarity: 267/566 - (47%)
• Gaps: 65/566 - (11%)

  Fly     6 STWIGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSV 70
            :|.:...|..|...||.|.::....|...:|.|.|  ..||::.....::.|..:||.| ||.::
Human     2 ATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPT--DGSHWLSMREALRDLHARGHQV-VVLTL 63

  Fly    71 PPKVTHKSINHIVVPMSA------EDEKVLNDGMAGMVKEKPSIWNT----MK-----SIFSSLA 120
            ...:..|..|...:...|      |.:::|       :....|.:.|    ||     :|.::::
Human    64 EVNMYIKEENFFTLTTYAISWTQDEFDRLL-------LGHTQSFFETEHLLMKFSRRMAIMNNMS 121

  Fly   121 LLIDKQ-VDVL-EDPRFQELYLNKGNKFDVVFVGFFFNTYQV-----ALGARF---NCPVIISWS 175
            |:|.:. |::| .:...:.|:   ...||||....|.....|     ::.|.|   |.|..:.:.
Human   122 LIIHRSCVELLHNEALIRHLH---ATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFK 183

  Fly   176 GPPMMMVNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRL 240
            |..       ..||. |.:|:  :.......|.|.||::|....|..:.|...::..|......|
Human   184 GTQ-------CPNPS-SYIPR--LLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASEL 238

  Fly   241 WSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-K 304
            :.::.|:.....   :.|:....|..:.:.| ||.:|.::.||||.. :...||.::.:.::. .
Human   239 FQREVSVVDLVS---HASVWLFRGDFVMDYP-RPIMPNMVFIGGINC-ANGKPLSQEFEAYINAS 298

  Fly   305 GKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQ 367
            |:||.::|||||.:  ..|..:....|...|..:.|.|:|::..  |.|.   :.|.:..|||||
Human   299 GEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQ 358

  Fly   368 DDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDE 432
            :|:|.||..:.||||||..||.|:..:||||:.:|:|.||..||.::...|.|:.|.:..:..::
Human   359 NDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSED 423

  Fly   433 FKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIAS 496
            .:.|:|.||.:..|.:.:...|.|::|||:.|.:..|:|.|:|:||.||.|:: |..| :.:...
Human   424 LENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQY 487

  Fly   497 NNLDIY-IIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVK 541
            ::||:. .:.|:||.:.||..|.. .:.:||..||..:|.|..|.|
Human   488 HSLDVIGFLLAVVLTVAFITFKCC-AYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	139/516 (27%)
		UDPGT	45..530	CDD:278624	140/514 (27%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	145/530 (27%)
		egt	<262..508	CDD:223071	87/253 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840