Protein Alignment Ugt37D1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_652627.2
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 151/529 - (28%)
• Similarity: 249/529 - (47%)
• Gaps: 67/529 - (12%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT-----HKSINHIVVPMSAEDEKVLNDGMAGMVKE 104
            ||::....|::.|:::||.:.|   |.|:|.     .|.....:.|:..:.|::.|        .
Human    37 SHWLSMKDIVEVLSDRGHEIVV---VVPEVNLLLKESKYYTRKIYPVPYDQEELKN--------R 90

  Fly   105 KPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELY-------------LN--KGNKFDVVFV--- 151
            ..|..|   :.|:..:.|...|.:...:.....||             ||  |.:|||.:|.
Human    91 YQSFGN---NHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPA 152

  Fly   152 ---GFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPE-LSSVPQMHISAPPGQPMNFQQR 212
               |       |.|......|.:..:.|.|..:.:....:|: :|.:|:.:...  ...|.|.||
Human   153 LPCG-------VILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKF--SDHMTFSQR 208

  Fly   213 MQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVP 277
            :.||...|....|...|..||.:....:..:|..:.|..|   .||:.......:.|.| ||.:|
Human   209 VANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQ---KVSVWLLRYDFVLEYP-RPVMP 269

  Fly   278 GVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQ 341
            .::.||||..|.:.| |.::.:.::. .|:||.::|||||.:  ..|..:....|...|..:.|.
Human   270 NMVFIGGINCKKRKD-LSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQT 331

  Fly   342 VIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVF 404
            |:|::..  |.|.   :.|.:..|||||:|:|.||..:.||||||..||.|:..:||||:.:|:|
Human   332 VLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 393

  Fly   405 ADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVV 469
            .||..||.::...|.|:.|.:..:..::.:.|:|.||.:..|.:.:...|.|::|||:.|.:..|
Human   394 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 458

  Fly   470 YWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFIINKIVWKFVWRKLFGKSN 532
            :|.|:|:||.||.|:: |..| :.:...::||:. .:.|:||.:.||..|.. .:.:||..||..
Human   459 FWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCC-AYGYRKCLGKKG 521

  Fly   533 KVSKGKKVK 541
            :|.|..|.|
Human   522 RVKKAHKSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_652627.2	GT1_Gtf-like	33..471	CDD:340817	125/455 (27%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	147/520 (28%)