Protein Alignment Ugt37D1 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 161/556 - (28%)
• Similarity: 263/556 - (47%)
• Gaps: 49/556 - (8%)

  Fly     5 RSTWIGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSS 69
            |:.|.|  |..|.|.||    :..|...|..|.|..... ||:....|:::.|..:||.|.||.
Human     3 RAGWTG--LLPLYVCLL----LTCGFAKAGKLLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVM- 59

  Fly    70 VPPKVT---HKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNT-MKSIFSSLA--------LL 122
              |:|:   .:|:|..|...|.  ...|.|.....:....:.|.. ::|.||.|.        |.
Human    60 --PEVSWQLGRSLNCTVKTYST--SYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF 120

  Fly   123 IDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLG 187
            ......:..|.:..| || |.:.||.||:. .|:...:.:...|:.|.::...|.....:.|...
Human   121 FSNCRSLFNDRKLVE-YL-KESCFDAVFLD-PFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQ 182

  Fly   188 NP-ELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFA 251
            .| .||.||::.:..  ...|.|::|:.|....|   ..::|..:.:....: :.|:....|..|
Human   183 CPAPLSYVPRLLLGF--SDAMTFKERVWNHIMHL---EEHLFCPYFFKNVLE-IASEILQTPVTA 241

  Fly   252 -QAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSL 314
             ....:.|:.......:.|.| :|.:|.:|.||||.. .:..|:|.:.:.::. .|:||.::|||
Human   242 YDLYSHTSIWLLRTDFVLEYP-KPVMPNMIFIGGINC-HQGKPVPMEFEAYINASGEHGIVVFSL 304

  Fly   315 GSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLK 377
            ||.:  ..|..:....|...|..:.|.|:|::..  |.|.   :.|.:..|||||:|:|.||..:
Human   305 GSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTR 364

  Fly   378 LFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIE 442
            .||||||..||.|:..:||||:.:|:|.||..||.::...|.|:.|.:..:..::.:.|:|.||.
Human   365 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 429

  Fly   443 NPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIA 505
            :..|.:.:...|.|::|||:.|.:..|:|.|:|:||.||.|:: |..| :.:...::||:. .:.
Human   430 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLL 493

  Fly   506 ALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVK 541
            |:||.:.||..|.. .:.:||..||..:|.|..|.|
Human   494 AVVLTVAFITFKCC-AYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	142/505 (28%)
		UDPGT	45..530	CDD:278624	143/503 (28%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	147/518 (28%)
		egt	<264..504	CDD:223071	86/246 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840