Protein Alignment Ugt37D1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_652627.2
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 153/536 - (28%)
• Similarity: 250/536 - (46%)
• Gaps: 82/536 - (15%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT---HKSINHIVVPMSA----EDE--KVLNDGMAG 100
            ||:....|:::.|..:||.|.||.   |:|:   .:|:|..|...|.    ||:  :.:....|.
Human    36 SHWFTMQSVVEKLILRGHEVVVVM---PEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQ 97

  Fly   101 MVKEKPSIWNTMKSIFSS-LALLIDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGA 164
            ...:..||::.:.|..|. |.|.......:..|.:..| || |.:.||.||:. .|:|..:.:..
Human    98 WKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVE-YL-KESSFDAVFLD-PFDTCGLIVAK 159

  Fly   165 RFNCPVIISWSG--------------PPMMMVNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQN 215
            .|:.|.::...|              |...:.|::||..:               .|.|::|:.|
Human   160 YFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSD---------------AMTFKERVWN 209

  Fly   216 ---------FASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFA-QAKRNVSLAFCNGHGISEG 270
                     |...|..|||.|.             |:....|..| ....:.|:.......:.:.
Human   210 HIVHLEDHLFCQYLFRNALEIA-------------SEILQTPVTAYDLYSHTSIWLLRTDFVLDY 261

  Fly   271 PIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKG 334
            | :|.:|.:|.||||.. .:..|||.:.:.::. .|:||.::|||||.:  ..|..:....|...
Human   262 P-KPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADA 322

  Fly   335 LSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVP 397
            |..:.|.|:|::..  |.|.   :.|.:..|||||:|:|.||..:.||||||..||.|:..:|||
Human   323 LGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVP 384

  Fly   398 MLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPL 462
            |:.:|:|.||..||.::...|.|:.|.:..:..::.:.|:|.||.:..|.:.:...|.|::|||:
Human   385 MVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPV 449

  Fly   463 SPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFIINKIVWKFVWR 525
            .|.:..|:|.|:|:||.||.|:: |..| :.:...::||:. .:.|:||.:.||..|.. .:.:|
Human   450 EPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCC-AYGYR 512

  Fly   526 KLFGKSNKVSKGKKVK 541
            |..||..:|.|..|.|
Human   513 KCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_652627.2	GT1_Gtf-like	33..471	CDD:340817	127/462 (27%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	149/527 (28%)