Protein Alignment Ugt37D1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_652627.2
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 143/548 - (26%)
• Similarity: 251/548 - (45%)
• Gaps: 103/548 - (18%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSS------------------VPPKVTHKSINHIVVPMSAEDE 91
            ||::...:|:|.|.::||.|||::|                  .|..:|.....:|::    :..
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIM----QQV 94

  Fly    92 KVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELYLN--------------- 141
            |..:|      .:|.|.|           |...::.::|.:  |.:::.|
Human    95 KRWSD------IQKDSFW-----------LYFSQEQEILWE--FHDIFRNFCKDVVSNKKVMKKL 140

  Fly   142 KGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGN----PELSSVPQMHISAP 202
            :.::||::|...||...:: |.|..|.|.:.|....|...:....|.    |....|....:|
Human   141 QESRFDIIFADAFFPCGEL-LAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLS-- 202

  Fly   203 PGQPMNFQQRMQNFASTLGFNA-LNIFLNHKYNKFYDRLWSKDKSM-PTFAQA----KRNVSLAF 261
              ..|.|.:|::|....|.|:. ..:....|:::||..:..:..:: .|..:|    .|| |.:|
Human   203 --DQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRN-SWSF 264

  Fly   262 CNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQP 325
            ...|        |.:|.:..:||:..| ...|||::::||:: .|::|.::|||||.:  .::..
Human   265 QFPH--------PFLPNIDFVGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTA 318

  Fly   326 EVVKTIFKGLSSLKQQVIWKWEDPKNTP-GKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVA 389
            |....|...|:.:.|:|:|:::.  |.| ....|....||:||:|:|..||.:.||||.|..|:.
Human   319 ERANVIATALAKIPQKVLWRFDG--NKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIY 381

  Fly   390 EAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFS 454
            ||.|||:||:.:|:|.|||.|...:.|.|..::|...|:...:...|:|.||.:|.|.:.:...|
Human   382 EAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLS 446

  Fly   455 QLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIY-IIAALVLYIVFIINKI 518
            .:..|:|:.|....|:|.|:|:.|.||.|::.....:.:...::||:. .:.|.|..::|::.|.
Human   447 IIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFVVTKF 511

  Fly   519 ----VWKFVWRKLFGKSNKVSKGKKVKK 542
                .|||           ..||||.|:
Human   512 CLFCFWKF-----------ARKGKKGKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_652627.2	GT1_Gtf-like	33..471	CDD:340817	122/470 (26%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	140/543 (26%)