DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	260/539 - (48%)
Similarity:	363/539 - (67%)	Gaps:	12/539 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGGLLVALLALQ--TMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT 75
            :|| :...||||  .:..|..||||||:|||.||||.::.||:.:.|||:|||||||:.:.|...
  Fly     1 MGG-ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSL 64

  Fly    76 HKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALL---IDKQVDVLEDPRFQE 137
            ||.||||:|||..:..:..|..:.||.|...|  |...|:|.|:..|   ..|..||::.|..::
  Fly    65 HKDINHILVPMEEDILQAFNSVVGGMTKTDNS--NAYVSMFRSVRQLSETFSKMGDVMKQPLVKD 127

  Fly   138 LYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNP-ELSSVPQMHISA 201
            ||.:..||||:|.||:|.|.||:||..:...|::::.|.||..: ..:|||| |:|.||.|.:|.
  Fly   128 LYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFL-GYLLGNPWEVSYVPGMSVSI 191

  Fly   202 PPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHG 266
            ..|:|:.|..|:.|...::........:..:..:.|..::..|.::|::....:|:||.|...||
  Fly   192 KGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHG 256

  Fly   267 ISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTI 331
            |||||||||||.||||||||||.:|:.||:::::||.:..:||||.|||||||.:|::...|:.:
  Fly   257 ISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQKM 321

  Fly   332 FKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGV 396
            |..||.|:|:|||||:|..|.||:|.||||.||:||.|:||||.:.||||||||||:.||||||.
  Fly   322 FNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGK 386

  Fly   397 PMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRP 461
            ||||||||.|||.|||.:|..|:|::..:.||:.|.|...|:||::|||||..:||||.||||||
  Fly   387 PMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRP 451

  Fly   462 LSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRK 526
            |||:|:::||.|||||:|||.|:|||:|||::||:||||:|.:....:..:..|.|:::..|..|
  Fly   452 LSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGK 516

  Fly   527 LFGKSN--KVSKGKKVKKQ 543
            |...|.  ||::..|:||:
  Fly   517 LRKNSRKAKVNQKHKLKKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	243/490 (50%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	236/488 (48%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	249/513 (49%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	236/472 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445673
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900