DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt37C1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	242/491 - (49%)
Similarity:	341/491 - (69%)	Gaps:	9/491 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 MSIMKTLAEKGHNVTVVSSVPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSI 115
            ||..|.|||.||||||||.:.|||.||.|:.||||::.|.|:.|.:.||.|...|.:|..||..:
  Fly     1 MSTAKALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNIITTMYLL 65

  Fly   116 FSSLALLIDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMM 180
            .:.|.:::..|.|:|:|||||.::   ..|||::.:|.|||.:|:.:..:...|||:.|..|...
  Fly    66 LNGLDVMVTSQADLLKDPRFQRVF---ETKFDLMILGSFFNDFQLGVAGKLKVPVIVDWMIPSNT 127

  Fly   181 MVNEVLGNP-ELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKD 244
            |::|.:.|| |:|.||.....|.  .||:|.:|.:|....:....|.|..|:|:|:.|:.::: |
  Fly   128 MIDEFVANPSEVSYVPNESTFAT--TPMSFFKRAENLVKHVILKYLTIRFNYKFNRIYNEIFT-D 189

  Fly   245 KSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGA 309
            |.|||.::.|:|:|:.|...|.||:|||||.||.:||:||||||.:|||||:||::|:|....||
  Fly   190 KDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFMENSSQGA 254

  Fly   310 ILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHP 374
            |..|.|||:|...::||:|..:||.||.|||.|||||||.:||||.::||.||.|||||||||||
  Fly   255 IFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGNASNIFYKDWLPQDDILAHP 319

  Fly   375 KLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKE 439
            ..|||:||||||.:.|:|||||||:|||:|.|.|.||..:|.||||:.|.|.|:..|.|:.||.|
  Fly   320 NTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITEDTFREAINE 384

  Fly   440 VIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIY-I 503
            |:||.||.:.::.||.|||||||:|::||::|.:||:|||||.::|||.|||.|:..:||||| :
  Fly   385 VLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVELHNLDIYAL 449

  Fly   504 IAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKK 539
            :.|:::::|| :.::..||::.||.||:...::.||
  Fly   450 VLAILIFLVF-LTRLTVKFLFSKLLGKAKVPARKKK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	232/462 (50%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	238/480 (50%)
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	240/482 (50%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	218/432 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445670
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900