DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	270/526 - (51%)
Similarity:	369/526 - (70%)	Gaps:	8/526 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSI 79
            |:....|.|..:...|:||||||:|:||||||.|:|||:.|.|.:.||||||||.:.||||||.|
  Fly     3 GVHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDI 67

  Fly    80 NHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELYLNKGN 144
            :.|||||..|.|:::.|.|..|..:|.|:.:||..:.:|:.::|:.|.::|.|||||.:|   ..
  Fly    68 HLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIY---ET 129

  Fly   145 KFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNP-ELSSVPQMHISAPPGQPMN 208
            |||::.:|:|.|.:|:.:..:...||||:|...|:..:::..||| |||.||.|...|.  |||.
  Fly   130 KFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVAT--QPMG 192

  Fly   209 FQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIR 273
            |.:|.:|...:|.|..:.:..::|..:.|:.:: .::.|||..:.::|:|:||...|.|||||||
  Fly   193 FLKRTENALKSLLFEFIFVVFDYKLTRIYNDVF-PEQDMPTLKELRKNISMAFVGSHLISEGPIR 256

  Fly   274 PNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSL 338
            |.||.:|||||||||.||||||:||.:|:...|.||:..|||||:|...::||:|:.|||.||.|
  Fly   257 PLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSEL 321

  Fly   339 KQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPV 403
            |:.|||||||.:||||.|:|||||.|||||||||||..|||||||||||:.|||||||||:|||:
  Fly   322 KENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPI 386

  Fly   404 FADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESV 468
            |.||||||..:..|||||.|.|.::..|..:.|:|||:||.||.:.:..||.||||||::.::||
  Fly   387 FGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSV 451

  Fly   469 VYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKLFGKSNK 533
            |:||||::||.||.::|||.||||||..||||||.:...:|.:..::.::|.|.||.|..||: |
  Fly   452 VFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNKFGGKA-K 515

  Fly   534 VSKGKK 539
            :|:.||
  Fly   516 ISQTKK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	256/487 (53%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	249/485 (51%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	243/469 (52%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	251/488 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445667
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900