DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	173/549 - (31%)
Similarity:	269/549 - (48%)	Gaps:	57/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSI- 79
            ||..||:.      ....|.|.|..:.:.||:.|..::.|.||..||.||::|....|...|:|
  Fly    14 LLFCLLSC------VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIK 72

  Fly    80 ----NHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELYL 140
                ..|:..|......:|......::|:   |.|     |..:.:.|.:.  :|::|...|| :
  Fly    73 DVPAKSILTSMQGRIANLLQSSKEPIIKQ---IIN-----FHEMGIEITEL--LLKEPSVIEL-M 126

  Fly   141 NKGNKFDVVFVGFFFNTYQVALGARFNCPVI-------ISWSGPPMMMVNEVLGNPELSSVPQMH 198
            .....||.|....|.|.........|..|:|       |||:       .:::|:|.    |..:
  Fly   127 KSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWN-------TDLVGSPS----PPSY 180

  Fly   199 ISAPPGQPMNFQQRMQNFASTLGFNAL----NIFLNHKYNKFYDRLWSK--DKSMPTFAQAKRNV 257
            :   |...:.|..|| :....:|..|.    .||||:.|....:.|:.|  ..:...|...::|.
  Fly   181 V---PSALLKFSDRM-SLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNT 241

  Fly   258 SLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEH 322
            :|...|.| :|....||..|.:||:||:.:..|..|||:||.||:|..:||.|.||:|||||.:.
  Fly   242 ALVLLNQH-VSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGAEHGVIYFSMGSNLKSKT 305

  Fly   323 IQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGG 387
            :..|..:.:....:.|||:|:||:|| .:.|||.||:....|.||||||||..:..||||.|...
  Fly   306 LPLEKRQALIDTFAQLKQRVLWKFED-TDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLS 369

  Fly   388 VAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKS 452
            ..|:.||..|.:.:|:|.||..|..:...:|||:.:....|...:..|||:::|.||:..:.::.
  Fly   370 TTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRD 434

  Fly   453 FSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYII----AALVLYIVF 513
            .|..|||:..:|.|..|||.|:|.||.||.:::|....:|||..:|||..:|    ...|||.:|
  Fly   435 MSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIF 499

  Fly   514 IINKIVWKFVWRKLFGKSNKVSKGKKVKK 542
            ::.::||:.: ::||.|.:.....:|.|:
  Fly   500 LLIRLVWRLL-QELFIKKDTSKPKQKAKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	161/508 (32%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	163/506 (32%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	125/366 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445703
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950