DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	176/544 - (32%)
Similarity:	272/544 - (50%)	Gaps:	63/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WIGCSLGGLLVALLAL--QTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSV 70
            |:   |...|:.:|||  |:.     |.:.|.:..:.|.||:.|..::.|.||..||.||:||..
  Fly     3 WL---LNSWLLLILALFGQSW-----GYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPF 59

  Fly    71 PPKVTHKSI-----NHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALL-IDKQVDV 129
            |.:...|:|     .:|:..|.....::|.:.      :||.:..     :..::|: :|....:
  Fly    60 PQRKPIKNIIDVETPNIITVMGVYKARILENA------KKPVLLR-----YPRISLMGLDITESL 113

  Fly   130 LEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSS- 193
            |::|:.||| |.:...||.|....|.|.........|..|:|...|.......::::|.|...|
  Fly   114 LKEPKVQEL-LKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSY 177

  Fly   194 VPQMHISAPPGQPMNFQQRMQNFASTLGF--------NALNIFLNHKYNKFYDRLWSKDKSMPTF 250
            ||  |.....|..|||.:|.||    |||        |.:|:   .::...|.:.:..:|.  .|
  Fly   178 VP--HSLLRFGDRMNFWERAQN----LGFQIYEFAYENLINL---PRHEALYRKYFPNNKQ--DF 231

  Fly   251 AQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSK-PDPLPEDIQEFLEKGKHGAILFSL 314
            .:.:::.||...|.|.....| ||..|.:||:||:.|..| |.|||::|::|:|:.:||.|.|||
  Fly   232 YRMRKDTSLVLLNNHVSISNP-RPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSL 295

  Fly   315 GSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLF 379
            ||||..:.:.....|.|.:.|..||.:||||:|: :....|..|:|...||||||||||.|:..|
  Fly   296 GSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEE-ETFVDKPDNVLISNWLPQDDILAHEKVIAF 359

  Fly   380 ITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENP 444
            |||.|.....|:.|||.|::.:|.|.||..|..:....|||:.:..|.|....|::||:.:..:|
  Fly   360 ITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDP 424

  Fly   445 KYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLD--------- 500
            .:.:.:|..|..|||:..:|.|..|||.|:|.||.||.:::|....:|||..:|||
  Fly   425 SFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVI 489

  Fly   501 ---IYIIAALVLYIVFIINKIVWK 521
               :..:..||.::|.|:|..::|
  Fly   490 GLTVIFVFLLVRFLVTIVNGFLYK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	165/514 (32%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	166/505 (33%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	131/363 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445704
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950