DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	179/534 - (33%)
Similarity:	273/534 - (51%)	Gaps:	31/534 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSIN 80
            :.:...||...|..:|.|.||........|.:|...|.:|.||.|||.|||:::...|.|...
  Fly     7 IAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNKETPNM-- 69

  Fly    81 HIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDV-LEDPRFQELYLNKGN 144
            ..:..:.|.:   ..|.|..:: ..|.:|..:    :::..:::|.:|| :||...|.| ||.|.
  Fly    70 RFIEALKAHE---FADEMMSLL-NVPLLWQQL----NAMDYILNKFIDVTMEDEGVQRL-LNSGE 125

  Fly   145 KFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISAPPGQPMNF 209
            .||:|...........|....||..::...|......::|..||....|...: :::|....|.|
  Fly   126 TFDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISYNPL-VTSPRTDRMTF 189

  Fly   210 QQRMQNFASTLGFNALNIF-----LNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISE 269
            .:|::|....:..:....|     :.:.|.|::      ..:..|..:...:.||.....|....
  Fly   190 LERLENHYEVIVEDIHRHFVHLPHMRNVYKKYF------PNAKKTLEEVMDSFSLILLGQHFSLS 248

  Fly   270 GPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKG 334
            .| ||.:|.:||:||:.:..||.||||||::|:|...||.|.||:|||:|.:.:..|...|:.|.
  Fly   249 YP-RPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGSPHGVIYFSMGSNVKSKDLPQETRDTLLKT 312

  Fly   335 LSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPML 399
            .:.|||:|:||:|| .:.|||.||:|.|||.||.||||||.:||||:|.|.....|:.|.|.|:|
  Fly   313 FAKLKQRVLWKFED-DDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPIL 376

  Fly   400 ALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSP 464
            .||.|.||..|..:....|:||.|.|..|..::.:.||:.::.:|.|||...:.|:.|||:|.|.
  Fly   377 GLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSA 441

  Fly   465 QESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLD-IYIIAALVLYIVFIINKIVWKFVWRKLF 528
            .:..|:||||||||:||.|:::....:|||..|:|| :.:|.|:.|.:..:|..:..|.    |.
  Fly   442 VDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKL----LG 502

  Fly   529 GKSNKVSKGKKVKK 542
            ||..|.....|:||
  Fly   503 GKKQKCLHADKLKK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	168/493 (34%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	166/491 (34%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	161/482 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	7.020