DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	152/545 - (27%)
Similarity:	261/545 - (47%)	Gaps:	70/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GCSLGGLLVALLALQTM-PQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPK 73
            |..:.|||:.:|....: |:.|...|||.||:....|.:::....::.|.::||.:|::|:|...
  Fly     4 GPGIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIM 68

  Fly    74 VTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQEL 138
            ...:.::||.||......|:|.|........|.:....:...|.:.:..      |||||..|||
  Fly    69 PHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKF------VLEDPGVQEL 127

  Fly   139 YLNKGNKFDVVFVGFFFNTYQVALGARFNCPVI------ISWSGPPMMMVNEVLGNPELSSVPQM 197
            ..|...|:.::.:....|.........||.|::      .||:      ::.::||    |.|.:
  Fly   128 LRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWN------IDFLVGN----SAPSV 182

  Fly   198 HISAPPGQPMNFQQRMQNFASTLGF-NALNIFLNHKYNKFY---DRLWSKDKSMP---------- 248
            :      :||          |.||: :.||: :...:|..|   :||..:...:|
  Fly   183 Y------EPM----------SALGYTSGLNL-IEKWHNLIYITEERLVERFIYLPRQIDLYKQHF 230

  Fly   249 -----TFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHG 308
                 :....:|..||...|.| .:.|.:|.|||.::|:.|:.:..||.||..::::.|::.:||
  Fly   231 PGATTSIHDLRRRFSLVLINQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHG 294

  Fly   309 AILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAH 373
            .|.||:|..|....:.|.:..::....:.||||||||.:.|:.. .:|.|:..:.|.||..||.|
  Fly   295 VIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMV-NQSRNVFARTWFPQRAILNH 358

  Fly   374 PKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIK 438
            |.:||||||||...:.|:.::.||:|.:|:|.||..|..::...|...:|....|..||...||:
  Fly   359 PNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIE 423

  Fly   439 EVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYI 503
            :::.|..|.:..:..||.:.|:|:|..::.::||||::||.||.||:.....|:.:...|:|:..
  Fly   424 DLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVS 488

  Fly   504 -----IAALVLYIVFIINKIVWKFV 523
                 |....:.::|    :.||.|
  Fly   489 VLFGRIGLSAIIVIF----LGWKLV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	143/517 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	140/509 (28%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	133/473 (28%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	137/506 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445700
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950