DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt302K1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	180/544 - (33%)
Similarity:	279/544 - (51%)	Gaps:	49/544 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT 75
            ||||              .:.|.|.|.|..|...|||.|..::.|.|.:.||.:||||..|.|..
  Fly    12 CSLG--------------YSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKP 62

  Fly    76 HKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQV-------DVLEDP 133
            ......:.||...|       .|.|.:   .::|.:::..::.  .|||...       .:.||.
  Fly    63 IPGYTDVSVPNVIE-------VMGGDI---GALWASIQKTYTQ--NLIDHYQMGFRITRGLFEDS 115

  Fly   134 RFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSS-VPQM 197
            .||: :|.....||.:....|:|.....|...||.|:|...:|..:..:.:::|:|..:| ||
  Fly   116 NFQD-FLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVP-- 177

  Fly   198 HISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKY----NKFYDRLWSKDKSMPTFAQAKRNVS 258
            ||..|....|:..:|:.|.| .||:.  .:.|::.:    .|.|...:..:|.  .|.:.:||.|
  Fly   178 HIMLPFNDHMSLYERLLNVA-FLGYE--RVLLDYYFLPTQEKLYKEFFPGNKR--CFYKMRRNAS 237

  Fly   259 LAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHI 323
            |...|.| :|....||:.|.:||:||:.:..|.:||||.|:.|:.:.:||||.||:|||||.:.:
  Fly   238 LVLINQH-VSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDL 301

  Fly   324 QPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGV 388
            .|..|:.|.|.|..|||:|:||:| ..|.|.|..|:....|.||.|||||||:..|:||.|....
  Fly   302 PPSKVQEILKALGGLKQRVLWKFE-LDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLST 365

  Fly   389 AEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSF 453
            .|:.||..|::.||:|:||..|......:|||:.|...||:..||:.||:.:...|.|.|.::..
  Fly   366 TESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGI 430

  Fly   454 SQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKI 518
            |..|||:..:|.|:.:||.|:|.||.|||:::|....:|:...:|:|:.:|..:|:.::.|:..|
  Fly   431 SFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPI 495

  Fly   519 VWKFVWRKLFGKSNKVSKGKKVKK 542
            ....:.:||..|..: ::..|||:
  Fly   496 TIYKLLKKLLLKGER-TQSTKVKR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	168/498 (34%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	167/496 (34%)
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	170/503 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445701
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950