DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt303B2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	153/518 - (29%)
Similarity:	238/518 - (45%)	Gaps:	94/518 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WIGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVV--SSV 70
            |:...|      ||.|....:..:.|||||||....||.|.:...::|.|.|:||.||:|  :..
  Fly     7 WLAFGL------LLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY 65

  Fly    71 PPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSI------WN---TMKSIFSSLALLIDKQ 126
            |.|:  ..:.||.|||       ||..|..::|.....      |.   .:.:||.:::..|
  Fly    66 PAKI--DGVRHIRVPM-------LNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAI--- 118

  Fly   127 VDVLEDPRFQELYLNKGNKFDVVFV-----------GFFFNTYQVALGARFNCPVIISWSGPPMM 180
               |.:...|.|..:|..:||::.|           ..|:|.  ..||  .:| :.::|.
  Fly   119 ---LNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNA--TLLG--ISC-MHMTWH----- 170

  Fly   181 MVNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFY-------- 237
             ::.:.||    ..|.::....|.                ||...|.||:...|..|
  Fly   171 -IDYLAGN----LAPSVYEPISPN----------------GFALDNTFLSRWSNWIYITEEKLLE 214

  Fly   238 --------DRLWSKDKSMPT--FAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPD 292
                    .||:.|....|.  ..:.:...|:...|.| .|.|.:|.|||.:||:.|:.:...|:
  Fly   215 RLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSH-FSMGRVRANVPNIIEVAGVHLSEPPE 278

  Fly   293 PLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSA 357
            |...::|::|::.:||||.||:|.::..:::...:.|.:......:||:|||| .:......||.
  Fly   279 PCGAELQKYLDEAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWK-SELSMLANKSE 342

  Fly   358 NILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQ 422
            ||.....:||..:||||.|:|||||.|...|.||..:|||||.||:|.||..|..::..:|....
  Fly   343 NIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKV 407

  Fly   423 LPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQ 485
            |....|:.|.....|||::|||.||:..|..:..:||||:||.::.::||||.:|:...:||:
  Fly   408 LDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMR 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	148/501 (30%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	140/481 (29%)
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	146/487 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445699
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950