DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	164/527 - (31%)
Similarity:	258/527 - (48%)	Gaps:	64/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGT-EGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSI 79
            |.|.||       || :||.||..|.....|||::..:|::.|.::||.||
  Fly     8 LFVCLL-------GTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVT-------------- 51

  Fly    80 NHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALL--ID---------------KQV 127
              .:.|:|...|. |......::..|...|..:.::..:.:.|  ||               |..
  Fly    52 --FITPLSLAKEN-LGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKST 113

  Fly   128 D-VLEDPRFQELYL--NKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLG-- 187
            | .|..|..|||..  :|..|||::.|..|.|...:.||..:..|.|...:.......::|.|
  Fly   114 DFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFV 178

  Fly   188 NPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKS-----M 247
            || ||.||.:.:|..  ..|:..:|::|...:   .|.::.....|....|.:..|..|     :
  Fly   179 NP-LSYVPNVFLSCT--DRMSLWERLENVVIS---TAEDVVREVSYYPQQDAVIRKHFSSLLPRV 237

  Fly   248 PTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILF 312
            ||..|.::|:|:...|.:.....| ||....:|.:||:.: ..|.||||.|:.:|:..:||||.|
  Fly   238 PTVKQLEQNISVILLNSYMPLTSP-RPMSQNMISVGGLHI-LPPKPLPEHIKNYLDNAEHGAIYF 300

  Fly   313 SLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLK 377
            ||||.::...:..|.::......:||||:|:||:||.: .|....|:..:|||||.||||||.:|
  Fly   301 SLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQ-LPNLPDNVKVEKWLPQADILAHPNVK 364

  Fly   378 LFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIE 442
            :||.|.|..|:.||.||.||:|.:|.:.||..|.....|:||.:.|...|:..|:.|:|:..:::
  Fly   365 VFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLK 429

  Fly   443 NPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAAL 507
            :|||...:...|:::|||||...::.:||..||:.|.||.|:.:..||:.:.....||   ::|:
  Fly   430 DPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLD---VSAI 491

  Fly   508 VLYIVFI 514
            :|.|..:
  Fly   492 ILAITLL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	159/514 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	153/497 (31%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	164/527 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	153/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454761
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940