DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	260/528 - (49%)
Similarity:	359/528 - (67%)	Gaps:	11/528 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSINH 81
            |:..:|:..:...::||||||:|.|.||||.|:.||..|.|||.|||||||:.:.|.|.||:|..
  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITV 73

  Fly    82 IVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIF---SSLALLIDKQVDVLEDPRFQELYLNKG 143
            |.||:|.|:.:.::|.:..|.|...|  |...|:.   ..:..:|.|..:.|.:.|.::||||:|
  Fly    74 IQVPLSKEEAQQMSDTIGAMSKNDNS--NMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRG 136

  Fly   144 NKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISAPPGQPMN 208
            ||||:|..|:|.|.:|:....:.|.|||:..:.||..::|.::|||...|...:...|...:.:.
  Fly   137 NKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAEGSKAVT 201

  Fly   209 FQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIR 273
            ||:|:.::..:|||...:.....:...:|..::..|..||.:::..:|.||.|.:.|..||||||
  Fly   202 FQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIR 266

  Fly   274 PNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSL 338
            ||||..|||||||:|.||||||::|.|||.....||||.|||||::|:|:.|:.|..:|..||.|
  Fly   267 PNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKL 331

  Fly   339 KQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPV 403
            |::|||||||.:|||||||||||.||||||||||||.:||||.||||||:.|:||||.|||:|||
  Fly   332 KERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPV 396

  Fly   404 FADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESV 468
            |||||.||:.:|.||:||.|.|.||:...|:.||.|::.||:||:.:||||.||||||::.:||.
  Fly   397 FADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESF 461

  Fly   469 VYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKLFGKSNK 533
            :||||||||||||||:|||||||:|||:||:||..:..::|..|.::.|.:.:|::|:.
  Fly   462 LYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRF------ 520

  Fly   534 VSKGKKVK 541
            :||.||.|
  Fly   521 ISKPKKEK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	249/489 (51%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	243/487 (50%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	246/482 (51%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	245/496 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445672
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900