DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	181/551 - (32%)
Similarity:	281/551 - (50%)	Gaps:	67/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLALQ------TMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKS 78
            :|||:      |:|...:.|.||.:|....||.:|..:..:|.||.:||.||.|::.|.|....:
  Fly     1 MLALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVN 65

  Fly    79 INHIVVPMSAEDEKVLNDGMAGMVKEKPSIW---NTMKSIFSSL--ALLIDKQVDVLEDPRFQEL 138
            ...:.:|....:.|.|.:.::|.:    ::|   |.:...|.|:  .:|.:|:|        .|.
  Fly    66 FRDVFIPDVFNNYKELINELSGPM----NLWQENNFINKFFVSVTRCVLTNKEV--------TET 118

  Fly   139 YLNKG-NKFDVVFVGFFFNTYQVALGARFNCPVI------ISWSGPPMMMVNEVLGNPE-LSSVP 195
            .|..| :.||::.|....:.......|.||.|:|      ..|:      ::.::||.. ||..|
  Fly   119 LLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWN------IDALVGNESPLSYTP 177

  Fly   196 QMHISAPPG--QPMNFQQRMQNFASTLGFNALNIFLNHKY------NKFYDRLWSKDKSMPTFAQ 252
                .|..|  ..|.|.:|:.||..|     ...:||:::      .|.|.:.:.:.........
  Fly   178 ----LATGGLTDRMTFLERLSNFVDT-----TVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTD 233

  Fly   253 AKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGS 316
            ..||.||...|.|.....| ||.||.:||:||:.:..||.|||:|::||:: .|:||.|.|||||
  Fly   234 LNRNFSLVLLNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGS 297

  Fly   317 NLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFIT 381
            |:..:.:..:....|.|..:||.|:|:||:||.| .|||.:|:...||.||.|||||||:|||||
  Fly   298 NVLSKDLPADRKDLILKTFASLPQRVLWKFEDDK-LPGKPSNVFISKWFPQPDILAHPKVKLFIT 361

  Fly   382 HAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKY 446
            |.|.....|:.:||.|:|.||.|.||..|..:...:|:||.|...|:...|.|..|:.:::.|::
  Fly   362 HGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRF 426

  Fly   447 AKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI--YIIAALVL 509
            |:..:..|:.|||:|:||.::.::|||||:||.||.||:.....:.|.|.::||:  .::...:|
  Fly   427 AQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALL 491

  Fly   510 YIVFIINKIVWKFVWRKL--FGKSNKVSKGK 538
            .:..|:.      |..||  ||.:.|..|.|
  Fly   492 LVAIIVG------VLGKLTDFGNAKKKLKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	169/510 (33%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	167/510 (33%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	164/486 (34%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	142/440 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445697
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940