DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	262/565 - (46%)	Gaps:	81/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77
            |.|||:.|.||    ...||..:| ||.... ||::....:::.|..:||...|::   |:||
  Rat    10 LSGLLLLLCAL----PWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLA---PEVT-- 63

  Fly    78 SINHIVVPMSAEDEKVLNDGMAGMVKE--KPSIWNTMKSIFS---SLALLIDKQVDVLEDPRF-- 135
                  |.:..||...|........||  :..:...:::.|.   ||.|::.:...|.....|
  Rat    64 ------VHIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQRMAAVNNVSTFYV 122

  Fly   136 -------------QELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLG 187
                         |.|   ..:.||||....||....| |......|.:.........:..|...
  Rat   123 RSCRGLLHNTALIQSL---NSSSFDVVLTDPFFPCGAV-LAMYLRVPAVFFLQSMLCELEFEATN 183

  Fly   188 NPELSS-VPQM------HISAPPGQPMNFQQRMQNFASTLGFNALNIFLNH-KYN---KFYDRLW 241
            :|..|| :|::      |        |:|..|::|....:.:    ::|.| .|.   :....|.
  Rat   184 SPNPSSYIPRLLTLNSDH--------MSFLDRVKNMLYPVPW----MYLCHVNYGSLARLASDLL 236

  Fly   242 SKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KG 305
            .::.|:   .:..|:.|:.......:...| ||.:|.::.||||...:: .||.::.:.::. .|
  Rat   237 QREVSV---VEILRHASVWLLRKDFVFYYP-RPFMPNMVFIGGINCANR-KPLSQEFEAYVNASG 296

  Fly   306 KHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQD 368
            :||.::|||||.:  ..|..:....|.:.|..:.|.|:|::..  |.|.   :.|.:..|||||:
  Rat   297 EHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL---AKNTILVKWLPQN 356

  Fly   369 DILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEF 433
            |:|.|||.:.||||:|..|:.|...:||||:.:|:|.||..||.::...|.|:.|.:..:..|:.
  Rat   357 DLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDL 421

  Fly   434 KAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASN 497
            :.|:|.||.|..|.:.:...|.|::|||:.|.:..|:|.|||:||.||.|:: |..| :.:...:
  Rat   422 ENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYH 485

  Fly   498 NLDIY-IIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVK 541
            :||:. .:.|:||.:|||:.|.. .:..||.||...:|.|..|.|
  Rat   486 SLDVIGFLLAIVLTVVFIVYKSC-AYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	141/522 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	143/520 (28%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	147/536 (27%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	94/287 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910