DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	161/574 - (28%)
Similarity:	261/574 - (45%)	Gaps:	99/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77
            |.|||:.|.||    ...||..:| ||.... ||::....:::.|..:||...|::   |:||
  Rat    12 LSGLLLLLCAL----PWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLA---PEVT-- 65

  Fly    78 SINHIVVPMSAED-----------------EKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDK 125
                  |.|..||                 .::|.:...|...:     :.:|:.|.::|.:
  Rat    66 ------VHMKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEPQ-----HFVKTFFETMASI--- 116

  Fly   126 QVDVLEDPRFQELYLN---------------KGNKFDVVFVGFFFNTYQVALGARF-NCPVIISW 174
                   .:|.:||.|               ..:.||||.....|..  .||.|:: ..|.:...
  Rat   117 -------KKFFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPC--GALLAKYLQIPAVFFL 172

  Fly   175 SGPPMMMVNEVLGNPELSS-VPQM------HISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHK 232
            ...|..:..|....|:.|| :|.:      |        |.|.||::|....|....:.......
  Rat   173 RSVPCGIDYEATQCPKPSSYIPNLLTMLSDH--------MTFLQRVKNMLYPLTLKYICHLSITP 229

  Fly   233 YNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPED 297
            |......|..::.|:   .:...:.|:....|..:.:.| ||.:|.::.||||....| .||.::
  Rat   230 YESLASELLQREMSL---VEVLSHASVWLFRGDFVFDYP-RPIMPNMVFIGGINCVIK-KPLSQE 289

  Fly   298 IQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANI 359
            .:.::. .|:||.::|||||.:  ..|..:....|.:.|..:.|.|:|::..  |.|.   :.|.
  Rat   290 FEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL---AKNT 349

  Fly   360 LYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLP 424
            :..|||||:|:|.|||.:.||||:|..|:.|...:||||:.:|:|.||..||.::...|.|:.|.
  Rat   350 ILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLN 414

  Fly   425 LATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLV 489
            :..:..|:.:.|:|.||.|..|.:.:...|.|::|||:.|.:..|:|.|||:||.||.|:: |..
  Rat   415 VLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAA 478

  Fly   490 H-MNFIASNNLDIY-IIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVK 541
            | :.:...::||:. .:.|:||.:|||:.|.. .:..||.||...:|.|..|.|
  Rat   479 HDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSC-AYGCRKCFGGKGRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	142/531 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	144/529 (27%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	148/545 (27%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	91/253 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910