DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-39

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504816.2	Gene:	ugt-39 / 3564933	WormBaseID:	WBGene00017329	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	144/564 - (25%)
Similarity:	223/564 - (39%)	Gaps:	135/564 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEK 105
            :||.|.|..  :|..:|.:.|||||..:   |.:..|..| :....|.:|          :|..|
Worm    27 AHSHSKFFA--TIADSLTDAGHNVTFFT---PTIVEKYRN-VSYTKSTKD----------VVHMK 75

  Fly   106 PS-----------------IWNTMKSIFSSLALLIDKQVDVLEDPRFQELYLNKG---------- 143
            ||                 .|..     .|.|..|...|.:     ||::|..:|
Worm    76 PSKKLKEYGEQMSTGDFVRYWTE-----DSTATEIIPVVRI-----FQKMYNEQGTVMKDNVGIL 130

  Fly   144 -----NKFDV-VFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEV-----LGNPELSSVPQM 197
                 .|||| :|..:.::.|  .|......|..|    |.:.:.::.     :|.|.:.||...
Worm   131 NELKKRKFDVIIFEAYIYSAY--PLMDYLEIPTFI----PSVSVAHDTSLAIEIGEPVMPSVVSD 189

  Fly   198 HISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAK-------- 254
            .:| |.|..::..:|        .|||..:       .::|.:    ...||....|
Worm   190 CLS-PFGDKLSITER--------AFNAFMV-------PYFDFM----IGYPTHRSFKPPYNPIDI 234

  Fly   255 RNV----SLAFCNGHGISEGPIRPNVPGVIEIGGIQVKS---KPDPLPEDIQEFLEKGKHGAILF 312
            |::    |..|.|.:...:.| ||.:...|:||||.|.|   :...|.|...|.| |.:...:|.
Worm   235 RSIVPEASFVFLNSNPFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDETWSEIL-KLREKTMLV 297

  Fly   313 SLGSNLKGEHIQPEVVKTIFKGLSSLKQQV--------IWKWEDPKNTPGKSA--NILYKKWLPQ 367
            |.||.|..:.:.       ||...:||..:        |||:||..:......  ||.:.||:||
Worm   298 SFGSMLYSKDMP-------FKNKIALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQ 355

  Fly   368 DDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATL-DVD 431
            ..:||..:|..|:||||.|.:.|..|.|.|.:..|...||..||..||.....::|....| |.:
Worm   356 TALLADSRLSAFLTHAGLGSINELSYLGKPAILCPQLFDQMRNAKMLVRHNGSIELSKYDLGDSE 420

  Fly   432 EFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIAS 496
            :...|.:.::.:..|||.....::...::|:.|:|.:|...|:..|......:......|.||..
Worm   421 KIVNAFQAILFDSSYAKNALKLAEQLENQPIKPKEMMVKHAEFAARFGRLPSLDPYSRKMTFIEY 485

  Fly   497 NNLDIYIIAALVLY-IVFIINKIVWKFVWRKLFGKSNKVS-KGK 538
            ..:|:..|:.:||. :||:|.| ::|.:       .||.| |||
Worm   486 FLIDVAAISMVVLIAVVFVITK-MFKIL-------CNKTSVKGK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	133/535 (25%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	136/549 (25%)
ugt-39	NP_504816.2	Glycosyltransferase_GTB_type	12..503	CDD:299143	133/536 (25%)
ugt-39	NP_504816.2	UDPGT	29..521	CDD:278624	141/560 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910