DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	167/558 - (29%)
Similarity:	256/558 - (45%)	Gaps:	67/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSV---- 70
            ||.....|:|||:|...   ::...|||:|...:.|||.....||:.|||.||:|.|:|..
  Fly     3 GCWKVFCLLALLSLVAF---SDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKD 64

  Fly    71 PPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQV------DV 129
            ||. .:|  :|::.|.:..|...|.|      .|:|     ...:|..:...|..::      ..
  Fly    65 PPN-GYK--DHLLPPSTLTDTISLED------FERP-----YSFLFHYVEFFILHKMGREDCNTT 115

  Fly   130 LEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSV 194
            |......|:..|....:||:.:..|.....:::...|..|||...|...|....|..|.|.:.|
  Fly   116 LHSRALTEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPS- 179

  Fly   195 PQMHISA---PPGQPMNFQQRMQNFASTLGFNAL---------NIFLNHKYNKFYDRLWSKDKSM 247
               :|||   ...|.|:|..|:.|:.:....|.|         |..:..::.          ..:
  Fly   180 ---YISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFG----------PGL 231

  Fly   248 PTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILF 312
            |:.....||.||...|.|....|| :|..|.|||:||:.: |.|.|||.|:|:.|:....|.||.
  Fly   232 PSTEDLVRNTSLMLVNQHFSLSGP-KPLPPNVIEVGGVHI-SPPKPLPSDLQKILDNAPKGVILI 294

  Fly   313 SLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLK 377
            |.||.||...:.......|.|.:..|:|:||||:|: ...|.|..|:..:|||||.||||||.||
  Fly   295 SWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYEN-DTLPNKPPNLHIRKWLPQRDILAHPNLK 358

  Fly   378 LFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIE 442
            :|::|.|..|..||....||::.:|::.||..|...||..|..|||.|..||.:....|:.:.::
  Fly   359 VFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKALD 423

  Fly   443 NPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAA- 506
             |.:....|..:..|.:|...|.|:.::|.|:|....||...|...||::.....:||:|.:.|
  Fly   424 -PSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVAL 487

  Fly   507 -LVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVKKQ 543
             |:|.::.::..|       ::| |..:....:|:|::
  Fly   488 SLLLPVITLLGLI-------RMF-KRREPKGDRKLKRK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	155/510 (30%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	153/508 (30%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	151/491 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454635
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940