DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	172/545 - (31%)
Similarity:	255/545 - (46%)	Gaps:	55/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGA---NILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77
            ||...|||....:..|.|   .:||:|.....|||.....|||.|||.||:|:|||..|.|  |.
  Fly     8 LLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDK--HP 70

  Fly    78 SINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLID--KQVD--VLEDPRFQEL 138
            ..::...|::..|:  |.:.:.....||    .|..|.|....||.|  ||..  .|.....|::
  Fly    71 VAHYKDFPLTGMDK--LTNSVDLKFFEK----RTFYSHFQEFFLLYDWGKQTCNLTLRSEALQQI 129

  Fly   139 YLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISA-- 201
             |.:..:|||:.:..|.....:.:..:...|||...|...|....|.:|.|.:.|    ||.|
  Fly   130 -LRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLIPS----HIPALF 189

  Fly   202 -PPGQPMNFQQRMQNFASTLGFN---------ALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRN 256
             ...|.|||..|:.|:.||...|         |.:..:.:|:.          ..:|:..:..:|
  Fly   190 MAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFG----------HDVPSVGELVKN 244

  Fly   257 VSLAFCNGHGISEGP-IRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKG 320
            .|:.|.|.|....|| :.|  |.|||:|||.:: |..|||.|:|..|:..:.|.||.|.||.::.
  Fly   245 TSMFFVNQHYSLSGPKVTP--PNVIELGGIHIQ-KSKPLPADLQRILDNAEEGVILISWGSMIRA 306

  Fly   321 EHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGK 385
            ..:.......|.:.::.|||:||||||: :..|.:..|:...|||||.|||.||.:|:|::|.|.
  Fly   307 NSLSAAKRDGIIRAVARLKQKVIWKWEN-ETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGL 370

  Fly   386 GGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTL 450
            .|.:||.|.|||::|.|::.||..|...||..|.|..|....:..:....|:|:.::. |:....
  Fly   371 MGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDK-KFHDAA 434

  Fly   451 KSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFII 515
            |..|..:..||.....:.::|.|:|....||..::...|.|:.....:||:|.:.||||
  Fly   435 KVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLALVL------ 493

  Fly   516 NKIVWKFVW-RKLFGKSNKVSKGKK 539
            ..|:..:|| .:|...|:...|.||
  Fly   494 GSIIASWVWLLRLCCGSSAAQKTKK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	159/506 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	158/502 (31%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	152/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454611
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940