DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt36F1

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	154/569 - (27%)
Similarity:	257/569 - (45%)	Gaps:	88/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSIN 80
            |.:||||....|:..:.|:|||:|.....|||.....:...|||:|||:::.|..|
  Fly     4 LPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFP--------- 59

  Fly    81 HIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDV---------------- 129
                                  .||| :.|....:|..:.||.| .||:
  Fly    60 ----------------------LEKP-VANYTDYVFQGMPLLTD-IVDLSNFESEWKPLGLPFKV 100

  Fly   130 -----------------LEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGP 177
                             |..|...:| |....::||:.:..|.|....|:....|.|||...|..
  Fly   101 PTYFMLHDWGLRSCKVALNSPLITQL-LKSPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCA 164

  Fly   178 PMMMVNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWS 242
            .|....:.:|:|.::.:..|:. .|....|:...|:.||   ..|:.:|...|.......|.|.:
  Fly   165 IMPWHYKRMGSPFINPIMPMNF-LPYTDEMSLIDRLNNF---FHFHTVNTLYNMITQPATDALIA 225

  Fly   243 K--DKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKG 305
            :  ...:|...:..:|.||...|.|....|| ||..|.|||:||:|| ....|||:.:.:.|::.
  Fly   226 ERFGPGLPPINEIVKNTSLMLINQHYALTGP-RPYAPNVIEVGGLQV-GPIKPLPQHLLDLLDRS 288

  Fly   306 KHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQ-QVIWKWEDPKNTPGKSANILYK-KWLPQD 368
            .:|.|..|.||.:....:.......:|:.:|.||: ..:.:|:..::...|..:.||. .||||.
  Fly   289 PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQR 353

  Fly   369 DILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEF 433
            |:|.|||::.||:|.|..|..||.:.|||||..|.:.||..|:..:...|:|:.:.....|.:..
  Fly   354 DLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHI 418

  Fly   434 KAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNN 498
            ...:: :|.:.|:|:.::..|:.:|.||:.|.:...:|.|:||::.||.|:||...|:|:|..|:
  Fly   419 TRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNS 482

  Fly   499 LDIYIIAALVLYIVFI-INKIVWKFVWRKLFGKS---NKVSKGKKVKKQ 543
            :|:.:....:|:::.: :.|::      |:|..:   .|:|:..|.|.|
  Fly   483 IDVLLFWLGILFLLIVALRKLI------KIFKTAFCRGKISRDTKTKTQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	141/523 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	138/522 (26%)
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	139/508 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	120/463 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454659
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940