DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	161/541 - (29%)
Similarity:	251/541 - (46%)	Gaps:	92/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTH--KSINHIV----VPMSAED------------E 91
            ||:.....|::.|:.:||.|.||  :|....|  ||:|..|    |..:.||            .
  Rat    36 SHWFTMQMIVEKLSHRGHEVVVV--IPEVSWHMGKSLNFTVKTYSVSYTLEDLNYHFKFFAHNQW 98

  Fly    92 KVLNDGMAGMVKEKPSIWNTMKSIFSSL-----ALLIDKQ-VDVLEDPRFQELYLNKGNKFD--- 147
            |....||..::|      ::.|..|..|     :|..||: |:.|:...|..::|   :.||
  Rat    99 KTQEVGMFSLLK------HSGKGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFL---DPFDVCG 154

  Fly   148 -----------VVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISA 201
                       |||.|..|..|   |.....||      .||             |.||:  |.:
  Rat   155 LILAKYFSLPSVVFSGGIFCHY---LDEGAQCP------SPP-------------SYVPR--ILS 195

  Fly   202 PPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMP-TFAQAKRNVSLAFCNGH 265
            .....|.|::|:.|..|.:...|...:    :.|....:.|:....| |.......||:......
  Rat   196 KFTDTMTFKERVWNHLSYMKERAFCPY----FFKTAVEIASEVLQTPVTMRDLFSPVSIWMFRTD 256

  Fly   266 GISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVK 329
            .:.|.| ||.:|.::.||||.. .:..||.::.:.::. .|:||.::|||||.:  ..|..:...
  Rat   257 FVLEFP-RPVMPNMVYIGGINC-HQGKPLSKEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAM 317

  Fly   330 TIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQ 392
            .|.:.|..:.|.|:|::..  |.|.   :.|.:..|||||:|:|.|||.:.||||:|..|:.|..
  Rat   318 EIAEALGRIPQTVLWRYTGTRPSNL---AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGI 379

  Fly   393 YHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLY 457
            .:||||:.:|:|.||..||.::...|.|:.|.:..:..|:.:.|:|.||.|..|.:.:...|.|:
  Rat   380 CNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLH 444

  Fly   458 RDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFIINKIVW 520
            :|||:.|.:..|:|.|||:||.||.|:: |..| :.:...::||:. .:.|:||.:|||:.|..
  Rat   445 KDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSC- 507

  Fly   521 KFVWRKLFGKSNKVSKGKKVK 541
            .:..||.||...:|.|..|.|
  Rat   508 AYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	149/510 (29%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	156/528 (30%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	157/532 (30%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	89/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910