DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	158/549 - (28%)
Similarity:	254/549 - (46%)	Gaps:	102/549 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSINHIVVPMSAEDEK-------VLNDGMAGMV 102
            ||::...:|:..|.::||.|||:.        .|..:::.|..:.|.|       |..|.:....
  Rat    34 SHWMNIKTILDELVQRGHEVTVLK--------PSAYYVLDPKKSPDLKFETFPTSVSKDELENYF 90

  Fly   103 KEKPSIW--NTMKSIFSSLALLIDKQVDVLEDPRFQELYLN---------------KGNKFDVVF 150
            .:...:|  ...:....|.:.|:...:|     .|.:.||:               :.:||||:
  Rat    91 IKLVDVWTYELQRDTCLSYSPLLQNMID-----GFSDYYLSLCKDTVSNKQLMAKLQESKFDVL- 149

  Fly   151 VGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSV---PQMHIS-------APP-- 203
                           .:.||.....     ::.|||..|.|.|:   |...|.       .||
  Rat   150 ---------------LSDPVAACGE-----LIAEVLHIPFLYSLRFSPGYKIEKSSGRFILPPSY 194

  Fly   204 --------GQPMNFQQRMQNFASTLGFNALNIFLNHKYN-KFYDRLWSKDKSMP-TFAQAKRNVS 258
                    |.||.|..|::|...||.|:    |..|.:| |.:|..:|:....| |.|:......
  Rat   195 VPVILSGMGGPMTFIDRVKNMICTLYFD----FWFHMFNAKKWDPFYSEILGRPTTLAETMGKAE 255

  Fly   259 LAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEH 322
            :.....:...|.| .|.:|.|..|||:|.: .|.|||:|:::|:: .|:||.::|||||.:..
  Rat   256 MWLIRSYWDLEFP-HPTLPNVDYIGGLQCR-PPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS-- 316

  Fly   323 IQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGG 387
            :..|....|...|:.:.|:|:||: |.|.......|....|||||:|:|.|||.|.|:||.|..|
  Rat   317 MTEEKANAIAWALAQIPQKVLWKF-DGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANG 380

  Fly   388 VAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKS 452
            |.||.|||:||:.:|:|.:|..|...:||.|..:.|.:.|:...:...|:||:|.||.|.|....
  Rat   381 VYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVW 445

  Fly   453 FSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDI--YIIAALVLYIVFI 514
            .|.::.|:|:.|.:..|:|.|:|:||.||.|:: ||.| :.:...::||:  :::....:..|..
  Rat   446 LSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLR-PLGHNLPWYQYHSLDVIGFLLTCSAVIAVLT 509

  Fly   515 INKIVWKFVWRKLFGKSNKVSKGKKVKKQ 543
            :...:  |::| ||     |.|.||:|.:
  Rat   510 VKSFL--FIYR-LF-----VKKEKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	148/516 (29%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	153/534 (29%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	156/544 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840