DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	161/537 - (29%)
Similarity:	261/537 - (48%)	Gaps:	78/537 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSS-----VPPKVTHKSINHIVVPMSAEDE------KVLNDGM 98
            ||::....|:..|.::||.|||:..     :.||.:......|.....::||      |:|:...
  Rat    34 SHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQNHFIKLLDVWT 98

  Fly    99 AGMVKE-----KPSIWNTMKSIFSSLALLIDKQVDVLED----PRFQELYLNKGNKFDVVFVGFF 154
            ..:.::     .|.:.|.:.. ||...|.|.|  |.:.:    .:.||      :||||:|..
  Rat    99 YELPRDTCLSYSPILQNLVYE-FSYFYLSICK--DAVSNKQLMTKLQE------SKFDVLFAD-- 152

  Fly   155 FNTYQVA-----LGARFNCPVIISWSGPPMMMVNEVLGNPEL--SSVPQMHISAPPGQPMNFQQR 212
                .||     :....:.|.:.|.|..|...:.:.:|...|  |.||.: :|...|: |.|..|
  Rat   153 ----PVASCGDLIAELLHIPFLYSLSFSPGHKLEKSIGKFILPPSYVPVI-LSGLAGK-MTFIDR 211

  Fly   213 MQNFASTLGFNALNIFLNHK-YNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNV 276
            ::|....|.|:.....|.|| ::.||..:..:.   .|..:....|.:.....:...:.| .|.:
  Rat   212 VKNMICMLYFDFWFEILRHKEWDTFYSEILGRP---TTVDETMSKVEIWLIRSYWDLKFP-HPTL 272

  Fly   277 PGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQ 340
            |.|..|||:..| ...|||:|::||:: .|:||.::|||||.:  .::..|....|...|:.:.|
  Rat   273 PNVDYIGGLHCK-PAKPLPKDMEEFVQSSGEHGVVVFSLGSMV--SNMTEEKANAIAWALAQIPQ 334

  Fly   341 QVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFA 405
            :|:||: |.|.......|....|||||:|||.|||.|.|:||.|..|:.||.|||:||:.:|:|.
  Rat   335 KVLWKF-DGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFG 398

  Fly   406 DQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVY 470
            |||.|...:||.|..:.|.:.|:...:|.:|::|||:||.|.|.:...|.::.|:|:.|.:..|:
  Rat   399 DQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVF 463

  Fly   471 WTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY--------IIAALVLYIVFIINKIVWKFVWRK 526
            |.|:::||.||.|:: ||.| :.:...::||:.        :||||.:..:.        |::|.
  Rat   464 WIEFIMRHKGAKHLR-PLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLL--------FMYRF 519

  Fly   527 LFGKSNKVSKGKKVKKQ 543
            .      |.|.||:|.:
  Rat   520 F------VKKEKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	154/504 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	156/522 (30%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	159/532 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910