DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	571	Identity:	152/571 - (26%)
Similarity:	257/571 - (45%)	Gaps:	100/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVV----SSVPPKVTH 76
            ||::.|.|:.:.  .|.|.||.:.|. |.||:||...:.:.|.|.|||||.:    :::|.....
Mouse     8 LLMSFLFLEVIL--LEAAKILTISTL-SASHYIVISRVSQVLHEGGHNVTKLLYESANIPDFRKE 69

  Fly    77 KSINHIVVPMSAED-EKVLNDGMAGMVKE---KPSIWNTMKSI---FSSLALLIDKQVDVLEDPR 134
            |....::.....|| ||...|....:.:|   ..|..:|:..|   |..|...:..:.|:::
Mouse    70 KPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHTLLKIHQYFGDLCSQLLSRKDIMD--- 131

  Fly   135 FQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVP---- 195
                :| |...||:|.           |.:...|.::|.          |.||...:|.:|
Mouse   132 ----FL-KNENFDLVL-----------LDSMDLCSLLIV----------EKLGKRFVSFLPFQFS 170

  Fly   196 QMHISAPPG-------------QPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSM 247
            .|....|..             ..|:|..|::||...|.|:.....:..:|:......: .:.|.
Mouse   171 YMDFGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREILSQYDSTIQEHF-VEGSQ 234

  Fly   248 PTFAQAKRNVSLAFCNGHGISEGPI---RPNVPGVIEIGGIQVKSKP-DPLPEDIQEFLEK-GKH 307
            |..:.......|.|.|    |:..:   ||..|..:.:||:  ..|| .|:|:|::.|:.: |..
Mouse   235 PVLSDLLLKAELWFVN----SDFALDFARPLFPNTVYVGGL--LDKPVQPIPQDLENFISQFGDS 293

  Fly   308 GAILFSLGSNLKGEHIQ-PEVVKTIFKGLSSLKQQVIW-----KWEDPKNTPGKSANILYKKWLP 366
            |.:|.:|||.:  ..|| .|::|.:....:.|.|.|:|     .|  ||:. ..:.|:....|||
Mouse   294 GFVLVALGSIV--SMIQSKEIIKEMNSAFAHLPQGVLWTCKTSHW--PKDV-SLAPNVKIMDWLP 353

  Fly   367 QDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVD 431
            |.|:||||.::||:||.|...|.||.:|||||:.:|.|.|||.|..::.|...|:.:.|.||..:
Mouse   354 QTDLLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAE 418

  Fly   432 EFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHM-----QSPLVHM 491
            .|...:|::||:.:|.....:...:....||:|.:.::.|.:::::..||||:     |.|. |.
Mouse   419 SFALTMKKIIEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPW-HE 482

  Fly   492 NFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVKK 542
            .::    ||::      |:::.::...:|..| :.|...:..:|...|||:
Mouse   483 QYM----LDVF------LFLLGLMLGTLWLSV-KVLVAVTRYLSIATKVKE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	141/530 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	138/528 (26%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	138/511 (27%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	84/268 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840