DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt-31

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	148/558 - (26%)
Similarity:	239/558 - (42%)	Gaps:	95/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSI- 79
            ||||          :|..|||........||.....:|..||.|.|||||.:.||........|
Worm    10 LLVA----------SEPLNILVYSPVFGGSHSKFMGNIADTLTEAGHNVTFLVSVADVTRRHEIG 64

  Fly    80 -----NHIVVP---MSAEDEKVLNDGM---AGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDP 133
                 |.|:|.   .|.:|.::..|.:   ...::.:||.:.|....|..:     .|....|..
Worm    65 VKLTKNVIIVDKPNFSQDDVEIDMDEVLRPLWTIQNRPSDFATCFEFFIQM-----MQTTCAEFT 124

  Fly   134 RFQELY--LNKGNKFDVVF--------VGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGN 188
            ..:|::  |:| .:|.|..        :|:|     .|||.:   ..|::.|......|....|.
Worm   125 SNREIFKKLSK-TEFHVAIAEPVSICGLGYF-----DALGIK---KTILASSTTHYEGVVRNSGE 180

  Fly   189 P-ELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQ 252
            | ::|.|| :| .|...:.|:..||..|:||           .|......:|::.::.|     :
Worm   181 PVDMSYVP-VH-GAYFDEKMDIFQRYTNWAS-----------EHVLAGNLERMFDQEMS-----E 227

  Fly   253 AKRNV--------------SLAFCNGHGISEGPIRPNVPGVIEIGGIQV---KSKPDPLPEDIQE 300
            .::|:              ||.|.|.:...:.| ||.:...:.||||.|   :.|.:.|||.|.:
Worm   228 YRKNLVQSTGHWRDLIPSASLMFTNSNPYLDFP-RPVLQKTVGIGGITVDMEQIKSEKLPEKINK 291

  Fly   301 FLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQ-QVIWKWE-DPKNTPGKSANILYKK 363
            .|||.::. :|.|.||.:|...:..:...:|...:.:... ..|||:| |.........|:.:.|
Worm   292 LLEKREYN-MLISFGSMVKSSTMPEKWRNSILSAIRNFPNVTFIWKYESDDLRWAENVENVHFLK 355

  Fly   364 WLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATL 428
            |:||..:|.:|::..|:||.|.|...|..:.|.|.:.:|:|.||..||..|  :.:|..|.|...
Worm   356 WIPQTALLNNPRVSAFLTHGGLGSTNELAFIGKPSIIVPIFGDQGRNAPML--ARHGGALVLQKF 418

  Fly   429 DVDEFKAAIK---EVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH 490
            |::..:..|.   :::.:..|||..|:.:.|....|.||:|.||..||:|........|...:..
Worm   419 DLENAEVLIDFIGKIVFDKSYAKNAKTLANLLNASPFSPKELVVKNTEFVGNFGPLTQMDPYIRK 483

  Fly   491 MNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKLF 528
            :|:......|||    |:|::|:....::..:|.||:|
Worm   484 LNWFQRTFADIY----LILFLVYASIIVIPIYVIRKVF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	139/531 (26%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	140/529 (26%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	140/530 (26%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	71/227 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910