DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt-38

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	144/559 - (25%)
Similarity:	228/559 - (40%)	Gaps:	106/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFT---SHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77
            ||:|||.  |:.......|.| ||.   :||.|.|..  :|..:|.:.||||...:.:..: .::
Worm     2 LLLALLF--TLYANVSSFNFL-VFCPLFAHSHSKFFA--TIADSLTDAGHNVAFFTPIIVE-KYR 60

  Fly    78 SINHI-----VVPMSAEDEKVLND-GMAGMVKEKPSIWN---------TMKSIFSSL----ALLI 123
            :.|:.     ||.|  |..|.|.: |......:....|.         |:..||..:    ..::
Worm    61 NFNYTKSTKDVVYM--EPSKKLKEYGRQMSTGDFVRYWTEDSTATEIITVVRIFQKMYNEQGTVM 123

  Fly   124 DKQVDVLEDPRFQELYLNKGNKFDV-VFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEV-- 185
            ...:::|.|        .|..|||| :|..|.|:.|  .|......|..|    |.:.:.::.
Worm   124 KDNIEILND--------LKKRKFDVIIFEAFIFSAY--PLMDYLEIPTFI----PSLSVAHDTAL 174

  Fly   186 ---LGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSM 247
               :|.|.:.||....:| |.|..::..:|        .|||..:       .::|.:    ...
Worm   175 AVEIGEPVMPSVVSDCLS-PFGDKLSITER--------AFNAFMV-------PYFDFM----IGY 219

  Fly   248 PTFAQAK--------RNV----SLAFCNGHGISEGPIRPNVPGVIEIGGIQVKS---KPDPLPED 297
            ||....|        |::    |..|.|.:...:.| ||.:...|:||||.|.|   :...|.|.
Worm   220 PTHRSFKPPYNPIDIRSIVPEASFVFLNSNPFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDET 283

  Fly   298 IQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQV--------IWKWEDPKNTPG 354
            ..|.| |.:...:|.|.||.|..:.:.       ||...:||..:        |||:||..:...
Worm   284 WSEIL-KLREKTMLVSFGSMLYSKDMP-------FKNKIALKNAMEKFKNVTFIWKYEDDSSDEF 340

  Fly   355 KSA--NILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVAS 417
            ...  ||.:.||:||..:||..:|..|:||||.|.:.|..|.|.|.:..|...||..|...||..
Worm   341 AKGIENIHFAKWVPQTALLADSRLSAFLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRH 405

  Fly   418 GYGLQLPLATLDVDE-FKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGA 481
            ...::|....|...| ...|.:.::.:..|||..:..::...::|:.|:|.:|...||..|....
Worm   406 NGSIELSKYDLGKSEKIIEAFQAILFDSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRL 470

  Fly   482 AHMQSPLVHMNFIASNNLDIYIIAALVL-YIVFIINKIV 519
            ..:......|:|:....||:..|...:| ::||::.|:|
Worm   471 PSLDPYSRKMSFVEYFLLDVAAICVFILTFVVFVVTKLV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	135/541 (25%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	132/527 (25%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	138/547 (25%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	133/529 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910