DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-37

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	130/549 - (23%)
Similarity:	226/549 - (41%)	Gaps:	118/549 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FTSHSP----SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK--SINHI-----VVPMSAEDEK 92
            |...||    ||......|..||:|.|||||..:   |.:..|  .||::     |:.:. ..||
Worm    19 FLIFSPLFGHSHTTFFAKIADTLSEAGHNVTFFT---PTIIRKFSKINYVKHTKHVIHLE-PSEK 79

  Fly    93 VLNDG--------------------MAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQE 137
            :...|                    |..|:|    ::|.|   |:..|.::.:.:|||:     |
Worm    80 LERYGNQMEDVDISRFWTDDSSMAEMFPMIK----LFNEM---FAEQAFVLGQNLDVLD-----E 132

  Fly   138 LYLNKGNKFDVVFVGFF------------FNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPE 190
            |   |..||||:....|            ..|:..:....|:..::||            :|.|.
Worm   133 L---KEMKFDVMIFERFAECAYPLLEYLEIETFIPSSSLLFDPNLLIS------------IGEPR 182

  Fly   191 LSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKR 255
            :.|...:.:|....: |...:|:.|..:...|::|  ...|::..|.....:.|     ..:.:.
Worm   183 IPSTVPLPMSKFTDK-MTMTERLLNAIAVPIFHSL--LPTHEFKSFRPPYQAID-----IQKMEH 239

  Fly   256 NVSLAFCNGHGISEGPIRPNVPGVIEIGGIQV---KSKPDPLPEDIQEFLEKGKHGAILFSLGSN 317
            ..|....|.:...:.| ||.:...::||||.|   ..|...:.|:....|:. :...||.|.||.
Worm   240 LSSFILSNSNPYIDYP-RPTLEKNVQIGGISVDVENLKIHKVNEEWDRILDM-RQKTILVSFGSV 302

  Fly   318 LKGEHIQPEVVKTIFKGLSSLKQ-QVIWKWE--DPKNTPGKSANILYKKWLPQDDILAHPKLKLF 379
            :..:.:..|..|.:.|.:....: ..|||:|  |......::.||.:..|:||..:||..:|..|
Worm   303 MLSKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLFASETENIHFSSWVPQTALLADRRLTAF 367

  Fly   380 ITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENP 444
            .||||.|.|.|..|.|.|.:..|:||||..|| |::|...|      ::::.::.....|.||
Worm   368 FTHAGLGSVNEVSYLGKPSIMCPIFADQMRNA-KMLARHNG------SIEISKYDLGNGEKIE-- 423

  Fly   445 KYAKTLKS--FSQLYR-----------DRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIAS 496
               |||::  |...||           ::|:.|:|.::...|:..:......:......::|:..
Worm   424 ---KTLRTILFDDSYRLSAEKLAHQLANQPVKPKELLLRHAEFAAQFGRLPSLDPYSRQLSFVEY 485

  Fly   497 NNLDIYIIAALVLYIVFIINKIVWKFVWR 525
            ..:|   :||::::...:|..::::.:.|
Worm   486 FLID---VAAILIFSSLLIVVVLFQIIKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	128/534 (24%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	127/539 (24%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	129/540 (24%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	124/528 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910