DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-15

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_506211.1	Gene:	ugt-15 / 183462	WormBaseID:	WBGene00008097	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	138/558 - (24%)
Similarity:	234/558 - (41%)	Gaps:	86/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVALLALQTMPQ----------GTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTV----- 66
            |:.||.|:.:..          |...:|.||              .|...|.:.||:||:
Worm     6 LLTLLLLELVCSYKVLVFNPAFGASHSNFLG--------------KISDILIDAGHDVTMLIPVC 56

  Fly    67 VSSVPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALL--------- 122
            :.|....|..|.:..|:........|::.:........|..||.....|....:::
Worm    57 MESKKDLVGSKKVKKIIRIDQEPRSKLMQEEAKTEEMIKKQIWKLDADITIFFSMIKNFSIASGY 121

  Fly   123 ----IDKQVDVLEDPRFQELYLNKGNKFDV-----VFVGFFFNTYQVALGARFNCPVIISWSGPP 178
                |.||..:||..|        ...||:     :|:..|.....:.:....|...::.
Worm   122 QCENIFKQTAILEQLR--------NEHFDLGITESLFICGFPLLDSIGVKTIINADSVLY----- 173

  Fly   179 MMMVNEVLGNPELSS-VPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWS 242
            :.:|...||.|..:| .|.::  |.....|:|::|::|....    |.:.:.:  :.:|...|.:
Worm   174 LDVVKHALGEPASTSYYPGVY--AKNIDRMSFRERVRNLFGM----AFSWYFS--WTRFQGELEA 230

  Fly   243 ----KDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPD---PLPEDIQE 300
                .:||: |:.......:..|.|.:...:.| .|.:|..:.|||:||.:...   .|.::..:
Worm   231 IKPYYNKSL-TWEDHINGAAYYFINSNQYLDYP-SPTLPKTVFIGGMQVNTNKHGKVKLEKEWDD 293

  Fly   301 FLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQV-IWKWEDPKNT-PGKSANILYKK 363
            .|...|.. :|.|.|||.....:..|..::..|..:|:.:.. |||:|....| ..:.:|:....
Worm   294 LLNLRKQN-VLVSFGSNAFSCDMPDEFKESFLKVFASMPETTFIWKYEQENATLADQLSNVKLTT 357

  Fly   364 WLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATL 428
            |:||:||||..:|.||:||.|.|...|..|.|.|.:.:|:.||||.||..|...|..|||....|
Worm   358 WMPQNDILADERLTLFVTHGGLGSSMELAYQGKPAVVIPLMADQPRNALMLTRHGGALQLDKTFL 422

  Fly   429 DVDE-FKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMN 492
            :..| .:.||:.|:|||.|.|..:..:.:...:|..|::.|:...::.::|.....:.|...|:|
Worm   423 NNSEKIREAIQTVMENPSYKKNAEKLANILSSQPHQPKDVVLKHCDFAVKHGDLKTLNSEGRHLN 487

  Fly   493 FIASNNLDIYIIAA--LVLYIVFIINKIVWKFVWRKLF 528
            .....::||.:.|.  ||..|.|||..|:  ||::|::
Worm   488 VFQYYSIDIALAAGLFLVTIISFIIFTII--FVFKKVY 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	126/532 (24%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	130/520 (25%)
ugt-15	NP_506211.1	UDPGT	19..506	CDD:278624	125/524 (24%)
ugt-15	NP_506211.1	Glycosyltransferase_GTB_type	<252..493	CDD:299143	74/242 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910