DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-21

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001293944.1	Gene:	ugt-21 / 183141	WormBaseID:	WBGene00007885	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	142/545 - (26%)
Similarity:	236/545 - (43%)	Gaps:	72/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVV-----SSVPPKVTHKSI-NHIVVPMSAEDE 91
            :|:.|    |  ||..|..:....|.:.|:||||:     :::..|.:.||. |.|.|......|
Worm    26 SNLFG----H--SHVKVLAAAADILTDAGNNVTVLMPVFDNNLRNKTSLKSTKNTIFVEAGPNVE 84

  Fly    92 KVLND---GMAGMVKEKPSIWNTMKSIFSSLALLIDKQ-VDVLEDPRFQELYLNKGNKFDVVFVG 152
            ::::|   .:|...||......||......:.....:| ..|:.:|...|..  |...:|:. :.
Worm    85 ELMSDMRQFLANAWKEDTGNPITMMKAAQDMGTAFAEQCTKVISEPGLLEKL--KAENYDLA-IT 146

  Fly   153 FFFNTYQVALGARFNCPVIIS-WSGPPMMMVNEVLGNPELSS-VPQMHISAPPGQPMNFQQRMQN 215
            ..|:|...||....|....:: .:......|.:|:|.|..|| ||  ...:..|..|...:|:.|
Worm   147 EPFDTCGYALFEAINIRAHVAILTANRFDHVTDVIGQPIASSYVP--GTQSETGDRMTMGERLGN 209

  Fly   216 FASTLGFNALNIFLNHKYNKFYDRLWSKD----KSMPTFAQAKRNV----SLAFCNGHGISEGPI 272
            :..         ||...|  |:..:..:|    ||:....::.|.:    |....|...:.:.|
Worm   210 YFQ---------FLVGSY--FFSLIGDRDFEAAKSVVPITRSWRAILPEASFILTNQIPLLDFP- 262

  Fly   273 RPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKG------KHGAILFSLGSNLKGEHIQPEV---V 328
            .|....::.|||:.||::...|..|     ||.      :...:..|.|||.|...:..|.   :
Worm   263 APTFDKIVPIGGLSVKTEKKNLKLD-----EKWSKILGIRKNNVFISFGSNAKSVDMPDEFKNSL 322

  Fly   329 KTIFKGLSSLKQQVIWKWEDPKNTPGKSANIL----YKKWLPQDDILAHPKLKLFITHAGKGGVA 389
            ..:||.:..  ...|||:|   ||.....|.|    ...||||:::||.|:|.:|:||.|.|.|.
Worm   323 ADVFKSMPD--TTFIWKYE---NTSDPIVNHLDNVHLGDWLPQNELLADPRLSVFVTHGGLGSVT 382

  Fly   390 EAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATL-DVDEFKAAIKEVIENPKYAKTLKSF 453
            |....|.|.:.:|:||||..||..|...|..:.:....| |....|..:::||::|||.:..|..
Worm   383 ELAMMGTPAVMIPLFADQGRNAQMLKRHGGAVVIEKNNLADTHFMKETLEKVIKDPKYLENSKRL 447

  Fly   454 SQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKI 518
            :::..::|.:|:|:::.:.|:..|......:.:...|.::|....|||..|.|::......|:.|
Worm   448 AEMLTNQPTNPKETLIKYVEFAARFGKLPSLDNYGRHQSYIEYFFLDIIAILAVISLFSLYISYI 512

  Fly   519 VWKFVWRKLFGKSNKVSKGKKVKKQ 543
            :.:.|.||:|     .||..:||.:
Worm   513 ILRAVIRKIF-----FSKCSEVKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	132/512 (26%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	135/518 (26%)
ugt-21	NP_001293944.1	UDPGT	32..526	CDD:278624	136/525 (26%)
ugt-21	NP_001293944.1	egt	<263..504	CDD:223071	73/250 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910