DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-27

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_491436.1	Gene:	ugt-27 / 182508	WormBaseID:	WBGene00015694	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	126/512 - (24%)
Similarity:	214/512 - (41%)	Gaps:	64/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HSPSHFIVHMSIM----KTLAEKGHNVTVVSSVPPKVTHKSIN-HIVVPM--------SAEDEKV 93
            :||:....|.:.|    .||.|.|||||.:..:......|.:. |:...:        :.::...
Worm    24 YSPAFAASHTNFMARLADTLTEAGHNVTFLVPIVDVARTKQLGVHVTTDVIIVEKDEHTTQESVP 88

  Fly    94 LNDGMAGMVKEKPSIWNTMKS---IFSSLALLIDKQVDVLEDPRFQELYLNKGNKFDVVFV---- 151
            .:|.|.....|:....|..:|   .|..:.|..:..:     .|.:.|...|...|||..|
Worm    89 FDDSMEAYWTEETHSSNVGESFQWFFDGMKLGCENLL-----RRHEILDQLKSRNFDVAIVEPLS 148

  Fly   152 ----GFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSS-VPQMHISAPPGQPMNFQQ 211
                |.   ..::.:|     ..|::.|......:...:|.|::.| :|.  :.:..|..|...:
Worm   149 VCGLGL---AKKLEIG-----KTILASSCAYYDYLFRHIGEPDVHSYLPS--LMSTTGDVMTTFE 203

  Fly   212 RMQN--FASTLGFNALNIFLNHK--YNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPI 272
            |::|  .|..:......:|.:.|  |.|.:      ...:|.:.......||.|.|.:...:.|
Worm   204 RLENHRVAEAMATAMYKMFDSEKAIYRKHF------GDEIPDWRDLLPAASLYFTNSNPYLDFP- 261

  Fly   273 RPNVPGVIEIGGIQV---KSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKG 334
            ||.:...:.||||.|   |.|...|.::....|.| ::..:|.|.||.:...|:..:..|.:.|.
Worm   262 RPILQKTVSIGGISVDTKKIKSQELDKEWNHILNK-RNLNMLISFGSMIHSSHMLDDAKKNLIKV 325

  Fly   335 LSSLKQ-QVIWKWE--DPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGV 396
            :.|... ..|||:|  |.....|.. ||.:.||:||..:|...:|..|:||.|.|...|..:.|.
Worm   326 IKSEPNVTFIWKYETNDTSFAFGID-NIYFSKWVPQSKLLNDARLTAFLTHGGLGSTNELAHFGK 389

  Fly   397 PMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFK---AAIKEVIENPKYAKTLKSFSQLYR 458
            |.:.:|:|.||..|...|  ..:|..:.:...::..:|   :|:|.|:.:..|.|.....:.|.:
Worm   390 PAVMVPIFGDQYRNGHML--QRHGCAIIVQKTELSNWKIVSSAVKSVLYDENYKKNAAHLADLLQ 452

  Fly   459 DRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFII 515
            ::|:.|:|.||.:.|:|.|......|.:....:|||..|.||:|:|.....::.|:|
Worm   453 NQPVKPKEIVVKYVEFVARFGPFPEMDAYGRQLNFIQRNLLDVYLIELFGHFLFFLI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	124/507 (24%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	124/509 (24%)
ugt-27	NP_491436.1	UDPGT	21..500	CDD:278624	124/501 (25%)
ugt-27	NP_491436.1	egt	<230..478	CDD:223071	71/258 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910