DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	134/536 - (25%)
Similarity:	222/536 - (41%)	Gaps:	74/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKV-------THKSINHIVVPMSAED 90
            |.||....|.|.||.::.......|...||:..:......|:       .|..:..:.....|.|
Worm    26 AKILVYCPSISKSHVLLCSKYADLLHNAGHDTVLFIPSYSKLLDNYDGAKHAKVWRLHNVTEAYD 90

  Fly    91 EKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLED-----PRFQELYLNKGNKFDVVF 150
            .|:   |....|.|     |:.......|....|..:|:..|     |..|.:.   ..|||:|
Worm    91 TKL---GTLANVME-----NSHIGFIDRLTFDADFWIDMCADLLGKLPEMQHII---DYKFDLV- 143

  Fly   151 VGFFFNTYQ---VALGARFNCPVIISWSGPPMM-MVNEVLGNPELSS-VPQMHISAPPGQPMNFQ 210
               .:|...   .|:...||.|..:..|...:| .|...||.|.|.| ||.:. ..|....|:|.
Worm   144 ---IYNEIDPCTPAIVRLFNIPKTVLLSSEAIMDKVAWNLGLPTLPSYVPSVE-ENPNHDRMSFF 204

  Fly   211 QRMQN----FASTL-----GFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHG 266
            :||.|    |.|.:     ..:.||:|.....:.|           |:.|:..|||||...|...
Worm   205 ERMSNVYKFFQSIVVHYLQDIHVLNLFRKEVSSDF-----------PSIAEIIRNVSLVLVNTDE 258

  Fly   267 ISEGPIRPN----VPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEV 327
            |.:.|...:    ..|::|.|    |.:...||:...::.:|||.|::..|.|:......:...:
Worm   259 IFDLPRSYSSKFVYVGMLEAG----KDENVTLPKKQDDYFKKGKSGSVFVSFGTVTPFRSLPERI 319

  Fly   328 VKTIFKGLSSLKQQ--VIWKWEDPKNTP---GKSANILYKKWLPQDDILAHPKLKLFITHAGKGG 387
            ..:|...:..|...  |:....|.:::.   ....|:....|:||..:|.|..||||::|.|...
Worm   320 QLSILNAIQKLPDYHFVVKTTADDESSAQFFSTVQNVDLVDWVPQKAVLRHANLKLFVSHGGMNS 384

  Fly   388 VAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKS 452
            |.|..|:||||:.:|||.||..|...:...|.|..:...|:..:.|..||..|:|...|:.::|.
Worm   385 VLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKETFFDAIHSVLEEKSYSSSVKR 449

  Fly   453 FSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINK 517
            .|.|.:::|.:.:|.|..|.::|:::..:.|......:::.|..|:||::....::..:.|:
Worm   450 ISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSIIEHNHLDLFFYLCIISLLNFV--- 511

  Fly   518 IVWKFVWRKLFGKSNK 533
                 |:||:|.:.::
Worm   512 -----VYRKIFKRKSQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	129/513 (25%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	129/519 (25%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	124/479 (26%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	134/532 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960