DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt-46

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_508112.1	Gene:	ugt-46 / 180404	WormBaseID:	WBGene00015141	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	585	Identity:	149/585 - (25%)
Similarity:	237/585 - (40%)	Gaps:	122/585 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVV-----------SS 69
            |:..|||  |.........||....:.|.||.|.:..:...||..||:|||:           :|
Worm     3 LIFVLLA--TFVNAAFSYKILVFSPATSKSHLISNGRLADELARAGHDVTVLELDFLGISQTTNS 65

  Fly    70 VPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSI------WNTMKSIFSSLALLIDKQVD 128
            |  ||..|.|  |.....:.:.|.:..|.:..|.|:||.      |...:::::.|.....|..|
Worm    66 V--KVAKKRI--IDGFQESTNFKNVLHGFSETVMEEPSFTDEIKGWWAYQNVYNDLCAEFLKMDD 126

  Fly   129 VLEDPRFQELYLNKGNKFDVVFV------GFFFNTYQVALGARF---NCPV---IISWSGPPMMM 181
            :     |.||   |..|||..|.      ||.: .:.:.:...|   :||.   :..::|.| |.
Worm   127 I-----FNEL---KNAKFDGFFAEQINLCGFGY-AHALEIPRHFLISSCPFAAPVYDFTGLP-MP 181

  Fly   182 VNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQN-FAS-------TLGFNALNIFLNHKYNKFYD 238
            .:.|....:||..|            .:.:|.:| |.:       ||..|.|.....||:.:.:.
Worm   182 TSTVAFAADLSISP------------TYTERARNLFVAVLTKLEFTLLNNRLQAHFQHKFGEHFP 234

  Fly   239 RLWSKDKSMPT-FAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEF- 301
            .|:|....:.. |......:.::            ...:..::.:||:.|       .:|:.|.
Worm   235 SLYSVTSDVDVIFVATDEIIDIS------------TTTLQNIVHVGGLGV-------DDDVAEMD 280

  Fly   302 ------LEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWED------------ 348
                  :.|||.|.|.||||:......|..:|::|:.        .::.|:.|
Worm   281 NVFASEMSKGKEGVIYFSLGTIANTTKIDSKVMRTVL--------DIVKKFPDYHFVIRADKYDL 337

  Fly   349 -PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNAD 412
             .:......:|.....||||..||.||:|||||||:|...:.||...|||::.:|...||..|:.
Worm   338 STREYAKSVSNAFVSDWLPQPAILHHPRLKLFITHSGYNSIVEAARAGVPLINIPFMFDQNLNSR 402

  Fly   413 KLVASGYGLQLPLATL--DVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYV 475
            .:...|:|::.....|  :.:|.:.||.|:|.|.||:...:....|.:.:|||..:.::..||:.
Worm   403 AVEKKGWGIRRHKKQLLTEPEEIEKAISEIIHNKKYSLKAQRIRDLIKSKPLSSSQLLIKTTEWA 467

  Fly   476 IRHHGAAHMQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWKFVWRKL--FGKSNKVSKGK 538
            |::||...::............|||: ||....|.|..:|..|   |.|.|.  ||...: .|||
Worm   468 IKNHGLDEIKFESRGQTTWTYYNLDV-IIPVFWLSISLVIPTI---FGWYKFSCFGHVEE-KKGK 527

Fly 539 538
Worm 528 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	134/546 (25%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	137/546 (25%)
ugt-46	NP_508112.1	UDPGT	19..527	CDD:278624	142/565 (25%)
ugt-46	NP_508112.1	egt	<213..503	CDD:223071	80/317 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960