DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt-53

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	130/533 - (24%)
Similarity:	227/533 - (42%)	Gaps:	70/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTH----KSINHIVVPMSAEDEKVL 94
            |||..:....|||.....:.:..|..:||||.||.:|..::.:    ..:..|.....|:
Worm    18 NILFYYAVIGPSHIAYLRNTIGKLLARGHNVDVVFAVYNELANLDLFPDVRRIYYNRHAD----- 77

  Fly    95 NDGMAGMVKEKPSIWNTMKSIFSSLALLIDK------QVDVLEDPRFQ--ELYLN--------KG 143
                       |..|....:.||:   :.:|      :.::..:..:|  ::.:|        |.
Worm    78 -----------PDYWKKNANHFSN---MFEKSPTPLGEFEIFHESGYQLCKIAINDLKLIEFLKS 128

  Fly   144 NKFDVVFVGFF---FNTYQVALGARFNCPVIISWSGPPMMMVNEV-LGNPELSSVPQMHISAPPG 204
            .|:|:.|...:   .|....|.|    .|.|.|....|:.:.:.| .|.|.::||  ...|..|.
Worm   129 GKYDIGFSSDYDPCGNILMTAAG----IPSIGSLIATPIFLPHIVSAGLPTVASV--YGTSLYPE 187

  Fly   205 QPMNFQQRMQNFASTLGFN-ALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGIS 268
            ...:...::.|......:: |::..::.|||....:.:.  .:.|.....:|.:.:.|.|.|...
Worm   188 HDSSLYDKIFNLIRLTYYHYAISPDMDRKYNNLITKRFG--NNFPDVGTIERGIDIIFVNSHDFL 250

  Fly   269 EGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFK 333
            |.. ||..|.:..|||:.:: |...||::.::.|...|...:|||.|:.:....: |..::..|.
Worm   251 EQQ-RPMSPKIKYIGGMAIR-KAKQLPDEFEKILSVPKSAYVLFSFGTQVPTAKM-PLPIRRNFV 312

  Fly   334 GLSSLKQQV--IWKWE----DPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQ 392
            |.......|  :||::    |.....|.. ||...:||||.::|...::||||:|.|.....|..
Worm   313 GAFKKFPNVTFLWKYDSLELDADIFQGVE-NIHRLEWLPQTELLHDNRVKLFISHMGLNSYLETA 376

  Fly   393 YHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLY 457
            ..|||:|::|:||||..||......|.||.|....|.....::|:.|::|||||....:|.|::.
Worm   377 TAGVPVLSIPLFADQQNNAQNTRDRGMGLLLDRDKLTTKNIESALHELLENPKYLSNARSISKMI 441

  Fly   458 RDRPLSPQESVVYWTEYVIRHHGAAH-MQSPLVHMNFIASNNLDIYIIAALVLYIVFIINKIVWK 521
            .::|....::.::|.|:..|:.|... ::.|...::       ..|.....:|.:||.|..|:..
Worm   442 LEKPDKANDTFIHWLEFTARNPGLGRVLKLPGAELS-------PFYYYCGDILLLVFCILFIILH 499

  Fly   522 FVWRKLFGKSNKV 534
            .|.|.:...|.|:
Worm   500 TVLRTINLPSRKI 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	122/509 (24%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	124/516 (24%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	121/505 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14449
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910