DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt-44

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_501933.1	Gene:	ugt-44 / 177939	WormBaseID:	WBGene00008486	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	136/564 - (24%)
Similarity:	238/564 - (42%)	Gaps:	107/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVF---TSHSPSHFIVHMSIMKTLA----EKGHNVTVVSSV--- 70
            ||:.:...||: .|.|....:.||   :.||      |:..|.|:|    ::|:|||::..:
Worm     9 LLIIVYYSQTI-NGIERPKKVLVFMPISGHS------HLKFMGTIANILQDEGYNVTLLLPILDE 66

  Fly    71 ----PPKVTHKSINHIVVPMS---------------AEDEKVLNDGMAGMVKEKPSIWN----TM 112
                ...:..|..|.|:|..|               .|:..|:|.|:.|.:|....:.|    :.
Worm    67 GLRDTTPLVRKIKNRILVEQSEELIEANAQFRAGGGRENTWVMNSGIIGFLKLGTKVANICKASC 131

  Fly   113 KSIFSSLALLIDKQVDVLEDPRF-----QELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVII 172
            |::|.:     :..::.|.|.||     :.||.          .||       ||.........|
Worm   132 KNVFQN-----EDLINYLRDQRFDVAISEPLYT----------CGF-------ALFDHLGIETTI 174

  Fly   173 SWSGPPMMMVNEVLGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYN-KF 236
            |......:.|:::.....:|:.....:.:...:.|....|.:|:..:        :.|:.:| |.
Worm   175 STDSHLGLEVSKIAHGASISTSYLPAVFSSGSERMTLIGRAKNYVES--------YFNYYFNSKI 231

  Fly   237 YDR-------LWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQV-KSKPDP 293
            |:.       ::...|.   :.:..|..:..|.|.:...:.| .|.....||||||.. ..|.:.
Worm   232 YENELAGIEGIYKNGKG---WRELSRKNAYMFVNSNPQMDIP-SPRTSKFIEIGGISSGPVKQER 292

  Fly   294 LPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQV-IWKWEDP-----KNT 352
            |||:....|...|.. :|.|.|:|.|...:..::.:::.|...|:.... |||:|:.     |..
Worm   293 LPEEYDRVLSLRKKN-VLISFGTNAKSMFMSDDMKESLIKTFESMPDTTFIWKYENTTVDIVKQY 356

  Fly   353 PGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVAS 417
            ..:..|::...|:||..:||.|:|.||:||.|.|...|..:.|.|.:.:|||.||..||..|  .
Worm   357 NKRINNVMLTDWMPQTALLADPRLTLFVTHGGLGSTNEVAFSGKPSIMVPVFGDQTRNARML--E 419

  Fly   418 GYGLQLPLATLDVDEFK---AAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHH 479
            .:.:.|.|...|:..||   ..|::::.:..|:...:..:|:.|::|.||:|..:.:..:|.| .
Worm   420 RHEVALVLTKYDLTNFKKVRGTIRKMLNDKSYSMKAEKLAQMLRNQPESPKEIFIKYFNFVAR-F 483

  Fly   480 GAAH-MQSPLVHMNFIASNNLD---IYIIAALVLYIVFIINKIV 519
            |..| :.|....|:||....:|   |..|.::.||:  |::|::
Worm   484 GKPHGLDSYAAEMSFIEFYYIDFMAILSIFSVALYM--IVSKVL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	131/546 (24%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	126/532 (24%)
ugt-44	NP_501933.1	UDPGT	27..510	CDD:278624	124/526 (24%)
ugt-44	NP_501933.1	egt	<250..519	CDD:223071	79/273 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910