DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	152/544 - (27%)
Similarity:	248/544 - (45%)	Gaps:	97/544 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVT---HKSINHIVVPMS-AEDEKVLNDGMAGMVKEK 105
            ||:.....:::.|..|||.|.|   |.|:|:   .|.:|..|...| :..::.||......:
  Rat    36 SHWFTMQMVVEKLLPKGHEVVV---VVPEVSWQLGKPLNFTVKTYSVSHTQEDLNREFKFFI--- 94

  Fly   106 PSIWNTMKS-----IFSSLA-----LLIDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQV 160
            .|.|.|.:.     :.:|.|     ||......:.:|.:..| || |.:.||.||:. .|:...:
  Rat    95 DSQWKTQQEGGVLPLLTSPAQGFFELLFSHCRSLFKDKKLVE-YL-KQSSFDAVFLD-PFDVCGL 156

  Fly   161 ALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQMHISAPPG-----QPMNFQQRMQNFASTL 220
            .:...|:.|.::...|.....:.|.      |..|......|.|     ..|.|::|:.|..|.:
  Rat   157 TVAKYFSLPSVVFSRGIFCHYLEEG------SQCPSPPSYVPRGILKLTDTMTFKERVWNLLSYM 215

  Fly   221 GFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPI------------- 272
            |.:|.                     .|:|.:...:::      ..:.:.|:
  Rat   216 GEHAF---------------------CPSFFKTATDIA------SEVLQTPVTMTDLFSPVSVWL 253

  Fly   273 ----------RPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPE 326
                      ||.:|.||.||||....: .||.::.:.::. .|:||.::|||||.:  ..|..:
  Rat   254 LRTDFTLELPRPVMPNVIHIGGINCHQR-KPLSKEFEAYVNASGEHGIVVFSLGSMV--SEIPEK 315

  Fly   327 VVKTIFKGLSSLKQQVIWKWED--PKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVA 389
            ....|.:.|..:.|.|:|::..  |.|.   :.|.:..|||||:|:|.|||.:.||||:|..|:.
  Rat   316 KAMEIAEALGRIPQTVLWRYTGTRPSNL---AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIY 377

  Fly   390 EAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFS 454
            |...:||||:.:|:|.||..||.::...|.|:.|.:..:..|:.:.|:|.||.|..|.:.:...|
  Rat   378 EGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLS 442

  Fly   455 QLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFIASNNLDIY-IIAALVLYIVFIINK 517
            .|::|||:.|.:..|:|.|||:||.||.|:: |..| :.:...::||:. .:.|:||.:|||:.|
  Rat   443 SLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYK 506

  Fly   518 IVWKFVWRKLFGKSNKVSKGKKVK 541
            .. .:..||.||...:|.|..|.|
  Rat   507 SC-AYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	140/513 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	147/531 (28%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	148/535 (28%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	91/247 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910